35929-79-4

Basic information

• Product Name: diethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• Synonyms: diethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS NO: 35929-79-4
• Molecular Formula: C₁₉H₂₂ClNO₄
• Molecular Weight: 363.83528
• Mol File: 35929-79-4.mol
• Article Data: 116

Chemical Properties

• Boiling Point: 472.1°C at 760 mmHg
• Flash Point: 239.3°C
• Appearance: /
• Density: 1.191g/cm³
• Vapor Pressure: 4.39E-09mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: diethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate(35929-79-4)
• EPA Substance Registry System: diethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate(35929-79-4)

Safety Data

• Hazardous Substances Data: 35929-79-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H22ClNO4/c1-5-24-18(22)15-11(3)21-12(4)16(19(23)25-6-2)17(15)13-7-9-14(20)10-8-13/h7-10,17,21H,5-6H2,1-4H3

Upstream product

• 141-97-9 ethyl acetoacetate 
• 104-86-9 4-chlorobenzylamine 
• 631-61-8 ammonium acetate 
• 104-88-1 4-chlorobenzaldehyde 
• 873-76-7 para-Chlorobenzyl alcohol 
• 539-88-8 4-oxopentanoic acid ethyl ester 
• 506-87-6 ammonium carbonate 
• 674-82-8 4-methyleneoxetan-2-one 
• 64-17-5 ethanol 
• 626-34-6 ethyl 3-aminobut-2-enoate 
• 123-54-6 acetylacetone 
• 57-13-6 urea 
• 41867-20-3 ethyl (E)-3-aminobut-2-enoate 
• 140429-26-1 N-pyridinium chloride 

Downstream Products

• 4350-45-2 diethyl 4-(4-chlorophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate 
• 54795-01-6 5-(4-chlorophenyl)-3-methylcyclohex-2-enone 
• 1270020-08-0 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-bis[2-(aminothioxomethyl)hydrazide] 
• 175547-82-7 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbohydrazide 
• 1262983-70-9 2,6-dimethyl-N₃,N₅-bis(4-oxo-2-phenylquinazolin-3(4H)-yl)-4-(4-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxamide 
• 1262983-75-4 1-(2-(phthalimido-N-oxy)ethyl)-2,6-dimethyl-N₃,N₅-bis(4-oxo-2-phenylquinazolin-3(4H)-yl)-4-(4-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxamide 
• 73257-49-5 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(4'-chlorophenyl)-1,4-dihydropyridine 

Relevant articles and documents

Boosting the catalytic performance of manganese (III)-porphyrin complex MnTSPP for facile one-pot green synthesis of 1,4-dihydropyridine derivatives under mild conditions

In this study, the metal complex (5,10,15,20-tetrakis-(4-sulfonatophenyl)-porphyrin manganese (III) chloride; denoted as MnTSPP) represents a promising efficient and reusable heterogeneous solid catalyst for facile and highly efficient one-pot synthesis of 1,4 dihydropyridine derivatives via three-component condensation reaction of aromatic aldehyde, ethyl acetoacetate, and ammonium acetate under green and mild reaction conditions. The simple operation, short reaction time (15 min), and the high efficiency (99%) are the special advantage of this protocol. Furthermore, the green aspects of this synthetic protocol were more studied by examination of the reusability of MnTSPP for four consecutive cycles without a significant loss of catalytic activity. Remarkably, the new synthesis presented advantages in terms of safety, commercially available catalyst, simplicity, stability, mild conditions, short reaction time, and excellent yields, using a mixture of H2O and C2H5OH environmental-friendly solvent, operationally facile, wide tolerance of starting materials, and excellent recoverable of the catalyst.

Dual solvent-catalyst role of deep eutectic solvents in Hantzsch dihydropyridine synthesis

Deep eutectic solvents are a class of new generation green solvents formed from two or more components, which furnish a new homogeneous liquid phase with lower melting point than the individual components. Here, for the first time, dual role of DES as cat

One-pot synthesis of 1,4-dihydropyridine derivatives using the Fe2ZnAl2O7 catalyzed Hantzsch three-component reaction

A facile, low-cost, and effective one-pot method was developed for the synthesis of 1,4-dihydropyridine derivatives with high yields through the three-component reaction of ammonium acetate, ethyl acetoacetate, and aromatic aldehydes using Fe2ZnAl2O7 as catalyst. The reaction was conducted at 70–80°C temperature under solvent free conditions. The developed method had some great advantages, including safe and clean reaction conditions, high to excellent product yields, short reaction time, and a novel and powerful heterogeneous catalyst. The developed heterogeneous solid catalyst had high efficiency and reusability in one-pot multi-component syntheses such that it was easily reused four to five times without significant loss in efficiency and product yield. The catalyst was characterized by scanning Electron Microscopy (SEM)/energy-dispersive X-ray spectroscopy (EDS) and X-ray diffraction techniques. N2 sorption isotherms of the prepared nanocomposite exhibited surface area 2.1313E+01 m2/g and total pore volume of 3.0957E-02 cm3/g. Substituted dihydropyridine derivatives were characterized and confirmed using 1H NMR and 13C NMR, and elemental spectral data.