3598-10-5

Basic information

• Product Name: 2-(4-chlorophenoxy)acetamide
• Synonyms: 2-(4-chlorophenoxy)acetamide;2-(4-chlorophenoxy)ethanamide;AcetaMide, 2-(4-chlorophenoxy)-
• CAS NO: 3598-10-5
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.60762
• Mol File: 3598-10-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 374.2°Cat760mmHg
• Flash Point: 180.1°C
• Appearance: /
• Density: 1.3g/cm³
• Vapor Pressure: 8.51E-06mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: 2-(4-chlorophenoxy)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenoxy)acetamide(3598-10-5)
• EPA Substance Registry System: 2-(4-chlorophenoxy)acetamide(3598-10-5)

Safety Data

• Hazardous Substances Data: 3598-10-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 2286, 1950 DOI: 10.1021/ja01161a515

InChI:InChI=1/C8H8ClNO2/c9-6-1-3-7(4-2-6)12-5-8(10)11/h1-4H,5H2,(H2,10,11)

Upstream product

• 621-88-5 phenoxyacetamide 
• 4122-68-3 4-chlorophenyloxyacetyl chloride 
• 64-19-7 acetic acid 
• 106-48-9 4-chloro-phenol 
• 122-88-3 4-Chlorophenoxyacetic acid 
• 3598-08-1 Ethyl 2-(4-chlorophenoxy)acetimidate hydrochloride 
• 79-07-2 Chloroacetamide 

Downstream Products

• 106-47-8 4-chloro-aniline 
• 103706-84-9 2-(4-Chloro-phenoxy)-N-(6-nitro-benzoimidazol-1-ylmethyl)-acetamide 
• 86245-30-9 1-(4-chloro-phenoxyacetamidomethyl)-4-nitrobenzimidazole 
• 35368-44-6 p-chlorophenoxythioacetamide 
• 122-88-3 4-Chlorophenoxyacetic acid 

Relevant articles and documents

PYRROLIDINE DERIVATIVES AS INHIBITOR OF FIBROBLAST ACTIVATION PROTEIN (FAP) AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME

The FAP inhibitor is represented by the following formula X. The present invention relates to a pyrrolidine derivative or a pharmaceutically acceptable salt thereof. Chem. X.

Synthesis and biological evaluation of 2-Phenoxyacetamide analogues, a novel class of potent and selective monoamine oxidase inhibitors

Monoamine oxidases (EC 1.4.3.4; MAOs), a family of FAD-containing enzymes, is an important target for antidepressant drugs. In this paper, a series of 2-phenoxyacetamide analogues were synthesized, and their inhibitory potency towards monoamine oxidases A (MAO-A) and B (MAO-B) were evaluated using enzyme and cancer cell lysate. 2-(4-Methoxyphenoxy)acetamide (compound 12) (SI = 245) and (2-(4-((prop-2- ynylimino)methyl)phenoxy)acetamide (compound 21) (IC50MAO-A = 0.018 μM, IC50MAO-B = 0.07 μM) were successfully identified as the most specific MAO-A inhibitor, and the most potent MAO-A/-B inhibitor, respectively. The inhibitory activities of these two compounds in living cells were also further evaluated utilizing HepG2 and SHSY-5Y cell lysates.