36047-55-9

Basic information

• Product Name: 5-ETHYL-5H-[1,2,4]TRIAZINO[5,6-B]INDOLE-3-THIOL
• Synonyms: 5-ETHYL-5H-[1,2,4]TRIAZINO[5,6-B]INDOLE-3-THIOL;CHEMBRDG-BB 5251353;ART-CHEM-BB B036226;5-ethyl-5H-[1,2,4]triazino[5,6-b]indole-3-thiol(SALTDATA: FREE)
• CAS NO: 36047-55-9
• Molecular Formula: C₁₁H₁₀N₄S
• Molecular Weight: 230.29
• Mol File: 36047-55-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 358.5°C at 760 mmHg
• Flash Point: 170.6°C
• Appearance: /
• Density: 1.46g/cm³
• Vapor Pressure: 2.54E-05mmHg at 25°C
• Refractive Index: 1.78
• CAS DataBase Reference: 5-ETHYL-5H-[1,2,4]TRIAZINO[5,6-B]INDOLE-3-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ETHYL-5H-[1,2,4]TRIAZINO[5,6-B]INDOLE-3-THIOL(36047-55-9)
• EPA Substance Registry System: 5-ETHYL-5H-[1,2,4]TRIAZINO[5,6-B]INDOLE-3-THIOL(36047-55-9)

Safety Data

• Hazardous Substances Data: 36047-55-9(Hazardous Substances Data)

Usage

General Description

5-ETHYL-5H-[1,2,4]TRIAZINO[5,6-B]INDOLE-3-THIOL is a chemical compound with a complex molecular structure. It consists of a triazinoindole core with a thiol group attached at the 3-position and an ethyl group at the 5-position. 5-ETHYL-5H-[1,2,4]TRIAZINO[5,6-B]INDOLE-3-THIOL is not commonly encountered in everyday life and is likely a synthetic molecule with potential applications in pharmaceuticals, materials science, or other fields of research. Its specific properties and potential uses would depend on its behavior in different chemical and biological contexts, which would require further investigation.

InChI:InChI=1/C11H10N4S/c1-2-15-8-6-4-3-5-7(8)9-10(15)12-11(16)14-13-9/h3-6H,2H2,1H3,(H,12,14,16)

Upstream product

• 4290-94-2 N-ethylisatin 
• 79-19-6 thiosemicarbazide 
• 91-56-5 indole-2,3-dione 

Downstream Products

• 112800-90-5 10-Ethyl-1-(4-nitro-phenyl)-1,2-dihydro-10H-2,3,4,5,10,10b-hexaaza-cyclopenta[a]fluorene 
• 112800-92-7 10-Ethyl-1-(4-methoxy-phenyl)-1,2-dihydro-10H-2,3,4,5,10,10b-hexaaza-cyclopenta[a]fluorene 
• 112800-91-6 1-(4-Chloro-phenyl)-10-ethyl-1,2-dihydro-10H-2,3,4,5,10,10b-hexaaza-cyclopenta[a]fluorene 
• 112800-93-8 10-Ethyl-1-phenyl-1,2-dihydro-10H-2,3,4,5,10,10b-hexaaza-cyclopenta[a]fluorene 

Relevant articles and documents

Design, synthesis, and biological evaluation of 1,2,3-triazole-linked triazino[5,6-b]indole-benzene sulfonamide conjugates as potent carbonic anhydrase I, II, IX, and XIII inhibitors

A series of 1,2,3-triazole-linked triazino[5,6-b]indole-benzene sulfonamide hybrids (6a– 6o) was synthesized and evaluated for carbonic anhydrase (CA, EC 4.2.1.1) inhibitory activity against the human (h) isoforms hCA I, II, XIII (cytosolic isoforms), and hCA IX (transmembrane tumor-associated isoform). The results revealed that the compounds 6a–6o exhibited Ki values in the low to medium nanomolar range against hCA II and hCA IX (Kis ranging from 7.7 nM to 41.3 nM) and higher Ki values against hCA I and hCA XIII. Compound 6i showed potent inhibition of hCA II (Ki = 7.7nM), being more effective compared to the standard inhibitor acetazolamide (AAZ) (Ki = 12.1 nM). Compounds 6b and 6d showed moderate activity against hCA XIII (Ki= 69.8 and 65.8 nM). Hence, compound 6i could be consider as potential lead candidate for the design of potent and selective hCA II inhibitors.

Triazino indole-quinoline hybrid: A novel approach to antileishmanial agents

A novel series of 1,2,4-triazino-[5,6b]indole-3-thione covalently linked to 7-chloro-4-aminoquinoline have been synthesized and evaluated for their in vitro activity against extracellular promastigote and intracellular amastigote form of Leishmania donovani. Among all tested compounds, compounds 7a and 7b were found to be the most active with IC50 values 1.11, 0.36 μM and selectivity index (SI) values 67, >1111, respectively, against amastigote form of L. donovani which is several folds more potent than the standard drugs, miltefosine (IC50 = 8.10 μM, SI = 7) and sodium stibo-gluconate (IC50 = 54.60 μM, SI ≥ 7).

TRIAZINE COMPOUNDS AND THEIR USE

A compound of formula (I) wherein R1 is hydrogen, alkyl, -alkyl-aryl, -alkyl-heterocycloalkyl or -alkyl-0-heterocycloalkyl; R2 is hydrogen, hydroxy, amino, nitro, alkoxy, alkyl, aryl or heteroaryl; R3 is hydrogen, alkyl or