36062-37-0

Basic information

• Product Name: Benzenesulfonamide, N-(3-chloro-4-oxo-1(4H)-naphthalenylidene)-
• CAS NO: 36062-37-0
• Molecular Formula: C16H10ClNO3S
• Molecular Weight: 331.779
• Mol File: 36062-37-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-(3-chloro-4-oxo-1(4H)-naphthalenylidene)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-(3-chloro-4-oxo-1(4H)-naphthalenylidene)-(36062-37-0)
• EPA Substance Registry System: Benzenesulfonamide, N-(3-chloro-4-oxo-1(4H)-naphthalenylidene)-(36062-37-0)

Safety Data

• Hazardous Substances Data: 36062-37-0(Hazardous Substances Data)

Upstream product

• 36942-41-3 N-(3-chloro-4-hydroxy-[1]naphthyl)-benzenesulfonamide 
• 98-10-2 benzenesulfonamide 
• 1010-60-2 2-chloro-1,4-naphthoquinone 
• 98-09-9 benzenesulfonyl chloride 
• 5959-56-8 4-amino-1-naphthol hydrochloride 
• 6009-31-0 1,4-naphthoquinonenmonobenzenesulfonimine 
• 36942-42-4 N-(4-hydroxy-naphthalen-1-yl)-benzenesulfonamide 

Downstream Products

• 107379-37-3 N-Phenylsulfonyl-2-piperidyl-1,4-naphthoquinone monoimine 
• 107379-41-9 N-(3-morpholino-4-oxo-4H-[1]naphthylidene)-benzenesulfonamide 
• 131535-26-7 (1-Benzenesulfonylamino-3-chloro-4-oxo-1,4-dihydro-naphthalen-1-yl)-phosphonic acid diethyl ester 
• 131535-37-0 C₂₀H₂₁ClNO₆PS 
• 131535-29-0 (1-Benzenesulfonylamino-3-chloro-4-oxo-1,4-dihydro-naphthalen-1-yl)-phosphonic acid diisopropyl ester 
• 131535-42-7 C₂₄H₂₉ClNO₆PS 
• 131535-27-8 (1-Benzenesulfonylamino-3-chloro-4-oxo-1,4-dihydro-naphthalen-1-yl)-phosphonic acid dibutyl ester 
• 131535-28-9 (1-Benzenesulfonylamino-3-chloro-4-oxo-1,4-dihydro-naphthalen-1-yl)-phosphonic acid bis-(2-chloro-ethyl) ester 
• 107379-32-8 C₃₀H₂₅NO₇S₃ 
• 107379-39-5 N-Phenylsulfonyl-2-(p-tolylsulfonylamino)-1,4-naphthoquinone monoimine 
• 107379-38-4 N-Phenylsulfonyl-2-methoxy-1,4-naphthoquinone monoimine 
• 107379-31-7 C₂₈H₂₁NO₇S₃ 
• 178970-82-6 4-p-chlorophenylsulfonylimino-2,2,3,3-tetrachloro-1,2,3,4-tetrahydronaphthalen-1-one 
• 113446-10-9 4-Methoxy-benzoic acid [3-chloro-4-oxo-4H-naphthalen-(1Z)-ylidene]-hydrazide 

Relevant articles and documents

Novel aromatic sulfonyl naphthalene-based boronates as 20S proteasome inhibitors

A novel series of non-peptide proteasome inhibitors (PIs) that act on chymotrypsin-like (ChT-L) of the proteasome were developed. These PIs bearing 4-aromatic sulfonyl naphthalene-based scaffold and Leu-boronic moiety as covalent bonding group displayed f

Identification of a novel family of BRAFV600E inhibitors

The BRAF oncoprotein is mutated in about half of malignant melanomas and other cancers, and a kinase activating single valine to glutamate substitution at residue 600 (BRAFV600E) accounts for over 90% of BRAF-mediated cancers. Several BRAFV600E inhibitors have been developed, although they harbor some liabilities, thus motivating the development of other BRAF V600E inhibitor options. We report here the use of an ELISA based high-throughput screen to identify a family of related quinolol/naphthol compounds that preferentially inhibit BRAFV600E over BRAF WT and other kinases. We also report the X-ray crystal structure of a BRAF/quinolol complex revealing the mode of inhibition, employ structure-based medicinal chemistry efforts to prepare naphthol analogues that inhibit BRAF V600E in vitro with IC50 values in the 80-200 nM range under saturating ATP concentrations, and demonstrate that these compounds inhibit MAPK signaling in melanoma cells. Prospects for improving the potency and selectivity of these inhibitors are discussed.