36076-25-2

Basic information

• Product Name: Dimethyl 2,2'-(1,4-phenylene)diacetate
• Synonyms: Dimethyl 2,2'-(1,4-phenylene)diacetate;1,4-Benzenediacetic acid, 1,4-dimethyl ester;WDAIQYFBXLZOHA-UHFFFAOYSA-N
• CAS NO: 36076-25-2
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.23716
• Mol File: 36076-25-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 51.5°C
• Boiling Point: 323.41°C (rough estimate)
• Appearance: /
• Density: 1.1995 (rough estimate)
• Refractive Index: 1.5360 (estimate)
• CAS DataBase Reference: Dimethyl 2,2'-(1,4-phenylene)diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Dimethyl 2,2'-(1,4-phenylene)diacetate(36076-25-2)
• EPA Substance Registry System: Dimethyl 2,2'-(1,4-phenylene)diacetate(36076-25-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 36076-25-2(Hazardous Substances Data)

Upstream product

• 622-75-3 1,4-phenylenediacetonitrile 
• 64-17-5 ethanol 
• 7325-46-4 1,4-phenylenediacetic acid 
• 67-56-1 methanol 
• 623-25-6 p-Xylylene dichloride 
• 201230-82-2 carbon monoxide 

Downstream Products

• 1251957-87-5 2-[4-(2-{[(2R)-2-hydroxy-2-(pyridin-3-yl)ethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide 
• 861448-74-0 [4-(2-hydroxy-2-methylpropyl)phenyl]acetic acid 
• 1251957-82-0 2-[4-(2-hydroxy-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide 
• 1251957-84-2 2-[4-(2-amino-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide 
• 1251957-86-4 2-[4-(2-{[(2R)-2-(6-chloropyridin-3-yl)-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide 
• 214614-59-2 2-(4-{2-[(tert-butyldimethylsilyl)oxy]ethyl}phenyl)ethan-1-ol 
• 157254-60-9 1,4-PBIT dihydrobromide 
• 4542-72-7 1,4-bis-(2-bromoethyl)benzene 
• 1208862-08-1 dimethyl α,α'-dibromo-1,4-benzenediacetate 
• 17833-56-6 ester monomethylique de l'acide p-phenylene diacetique 
• 150493-06-4 dimethyl 2,2'-(1,4-phenylene)diisobutyrate 

Relevant articles and documents

FUNCTIONALIZED LONG-CHAIN HYDROCARBON MONO- AND DI-CARBOXYLIC ACIDS AND THEIR USE FOR THE PREVENTION OR TREATMENT OF DISEASE

This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof. This invention further provides methods for treating a disease, including but not limited to, liver disease or an abnormal liver condition; cancer (such as hepatocellular carcinoma or cholangiocarcinoma); a malignant or benign tumor of the lung, liver, gall bladder, bile duct or digestive tract; an intra- or extra-hepatic bile duct disease; a disorder of lipoprotein; a lipid-and-metabolic disorder; cirrhosis; fibrosis; a disorder of glucose metabolism; a cardiovascular or related vascular disorder; a disease resulting from steatosis, fibrosis, or cirrhosis; a disease associated with increased inflammation (such as hepatic inflammation or pulmonary inflammation); hepatocyte ballooning; a peroxisome proliferator activated receptor-associated disorder; an ATP citrate lyase disorder; an acetyl-coenzyme A carboxylase disorder; obesity; pancreatitis; or renal disease.

Iridium-Catalyzed α-Methylation of α-Aryl Esters Using Methanol as the C1 Source

IrCl(cod)2]/dppe-catalyzed α-methylation of aryl esters using methanol as the C1 source was developed. This methylation process is useful in several fields including organic chemistry, biochemistry, and medicinal chemistry. Readily available methanol as methylation reagent was successfully adapted. The reaction processed high atom economy and efficient. By applying the reaction system, the synthesis method of naproxen was provided.

Synergistic Catalysis for the Umpolung Trifluoromethylthiolation of Tertiary Ethers

The first transition-metal-free, site-specific umpolung trifluoromethylthiolation of tertiary alkyl ethers has been developed, achieving the challenging tertiary C(sp3)–SCF3 coupling under redox-neutral conditions. The synergism of organophotocatalyst 4CzIPN and BINOL-based phosphorothiols can site-selectively cleave tertiary sp3 C(sp3)–O ether bonds in complex molecules initiated by a polarity-matching hydrogen-atom-transfer (HAT) event. The incorporation of several competing benzylic and methine C(sp3)?H bonds in alkyl ethers has little influence on the regioselectivity. Selective difluoromethylthiolation of C?O bonds has also been achieved. This represents not only an important step forward in trifluoromethylthiolation but also a promising means for site-selective C?O bond functionalization of unsymmetrical tertiary alkyl ethers.