361147-87-7

Basic information

• Product Name: (R)-3-Hydroxy-2-((R)-2-methoxy-1-phenyl-ethylamino)-propionic acid tert-butyl ester
• Synonyms: (R)-3-Hydroxy-2-((R)-2-methoxy-1-phenyl-ethylamino)-propionic acid tert-butyl ester
• CAS NO: 361147-87-7
• Molecular Weight: 295.379
• Mol File: 361147-87-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-3-Hydroxy-2-((R)-2-methoxy-1-phenyl-ethylamino)-propionic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-Hydroxy-2-((R)-2-methoxy-1-phenyl-ethylamino)-propionic acid tert-butyl ester(361147-87-7)
• EPA Substance Registry System: (R)-3-Hydroxy-2-((R)-2-methoxy-1-phenyl-ethylamino)-propionic acid tert-butyl ester(361147-87-7)

Safety Data

• Hazardous Substances Data: 361147-87-7(Hazardous Substances Data)

Upstream product

• 262378-77-8 (S)-1-((R)-2-Methoxy-1-phenyl-ethyl)-aziridine-2-carboxylic acid tert-butyl ester 
• 64715-85-1 (R)-2-methoxy-1-phenylethylamine 
• 138034-79-4 tert-butyl 2,3-dibromopropionate 
• 262378-74-5 (R)-1-((R)-2-Methoxy-1-phenyl-ethyl)-aziridine-2-carboxylic acid tert-butyl ester 

Downstream Products

• 312-84-5 D-Serine 

Relevant articles and documents

The origin of chemical and configurational stability of chiral nonracemic tert-butyl aziridinecarboxylate anions

The origin of good chemical and configurational stability of aziridine ester anions derived from (R)-(-)-phenylglycinol has been investigated. Kinetic acidity seems to play an important role in the deprotonation step and chemical stability of the anionic species. Spectroscopic investigations showed that the good overall retention of configuration was governed by the directing effect of the nitrogen atom, which acts as a stereogenic centre in the alkylation step of the enolate intermediate.