361201-97-0

Basic information

• Product Name: C₅₇H₇₀N₄O₁₀
• Synonyms: C₅₇H₇₀N₄O₁₀
• CAS NO: 361201-97-0
• Molecular Weight: 971.204
• Mol File: 361201-97-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅₇H₇₀N₄O₁₀(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₇H₇₀N₄O₁₀(361201-97-0)
• EPA Substance Registry System: C₅₇H₇₀N₄O₁₀(361201-97-0)

Safety Data

• Hazardous Substances Data: 361201-97-0(Hazardous Substances Data)

Upstream product

• 361201-96-9 methyl 4-benzyl-1,2,3,4,4a,5,6,8-octahydro-5-[(2S)-2-ethyl-2,3-(isopropylidenedioxy)-propyl]-pyrido[2,3-d]carbazole-7-carboxylate 
• 360787-29-7 dimethyl 3-[3-[dibenzylamino]propyl]indole-2-propanedioate 
• 360787-36-6 dimethyl 3-[3-[benzylamino]propyl]indole-2-propanedioate 
• 360787-37-7 methyl 3-benzyl-2-oxo-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate 
• 360787-41-3 methyl 3-benzyl-2-thioxo-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate 
• 360787-44-6 methyl 3-benzyl-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate 
• 4414-76-0 1H-indole-3-propiononitrile 
• 6245-89-2 Homotryptamine 
• 120-72-9 indole 
• 360788-11-0 2-{3-[3-(benzyl-tert-butoxycarbonyl-amino)-propyl]-1H-indol-2-yl}-malonic acid dimethyl ester 
• 360788-10-9 benzyl-[3-(1H-indol-3-yl)-propyl]-carbamic acid tert-butyl ester 
• 87400-38-2 N-benzyl-3-(1H-indol-3-yl)propan-1-amine 
• 361202-03-1 4-benzyl-7-chloro-5-(4-ethyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1,2,3,4,4a,5,6,7-octahydro-pyrido[2,3-d]carbazole-7-carboxylic acid methyl ester 
• 2182-14-1 vindoline 

Downstream Products

• 360787-52-6 C₆₁H₇₄N₄O₁₂S 
• 360787-92-4 C₆₁H₇₄N₄O₁₂S 
• 360787-51-5 C₅₄H₆₈N₄O₁₀ 
• 360787-91-3 C₅₄H₆₈N₄O₁₀ 
• 360787-50-4 C₅₇H₇₂N₄O₁₀ 

Relevant articles and documents

Syntheses of 5a′-homo-vinblastine and congeners designed to establish structural determinants for isolation of atropisomers

The syntheses of 5a′-homo-vinblastine (3a) and its C-20′ methyl congener 62a were achieved. In contrast to vinblastine, these compounds did not allow isolation of atropisomers because of their lower conformational inversion barrier. However, annelation of a six-membered ring to the conformationally mobile D′-piperidine ring provided an isolated atropisomer 81a, which could be converted to its lower energy conformation 65a on heating. The 5a′-homo-vinblastine congeners 3a, 62a, and 65a showed vinblastine-like inhibition of tubulin polymerization and cytotoxicity to L1210 leukemia cells, albeit at lower potency for the latter activity, than that found with the corresponding compounds in the vinblastine series.