36132-95-3

Basic information

• Product Name: 4-Methoxy-1,2-benzenedimethanol
• Synonyms: 4-Methoxy-1,2-benzenedimethanol;(2-Hydroxymethyl-4-methoxyphenyl)methanol;4-METHOXYBENZENE-1,2-DIMETHANOL
• CAS NO: 36132-95-3
• Molecular Formula: C₉H₁₂O₃
• Molecular Weight: 168.18978
• Mol File: 36132-95-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 70-72 °C
• Boiling Point: 336.9±32.0 °C(Predicted)
• Appearance: /
• Density: 1.192±0.06 g/cm3(Predicted)
• Refractive Index: 1.563
• Storage Temp.: 2-8°C
• PKA: 14.33±0.10(Predicted)
• CAS DataBase Reference: 4-Methoxy-1,2-benzenedimethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-1,2-benzenedimethanol(36132-95-3)
• EPA Substance Registry System: 4-Methoxy-1,2-benzenedimethanol(36132-95-3)

Safety Data

• Hazardous Substances Data: 36132-95-3(Hazardous Substances Data)

Usage

General Description

4-Methoxy-1,2-benzenedimethanol, also known by its IUPAC name as 4-Methoxybenzene-1,2-dimethanol, is an organic compound featuring a phenol group as part of its structure. It consists of a benzene ring that bears a methoxy group (-OCH3) and two hydroxymethyl groups (-CH2OH) at relative positions 4, 1, and 2, respectively. This substance is generally characterized by its physical properties such as a white crystalline solid appearance, a melting point between 75-78°C, and a high boiling point. Given its structural characteristics, 4-Methoxy-1,2-benzenedimethanol is utilized in a variety of chemical syntheses. However, exposure to this chemical should be limited as it can cause skin, eye, and respiratory irritation.

InChI:InChI=1/C9H12O3/c1-12-9-3-2-7(5-10)8(4-9)6-11/h2-4,10-11H,5-6H2,1H3

Upstream product

• 1885-13-8 4-methoxyphthalic acid 
• 22479-95-4 dimethyl 4-hydroxyphthalate 
• 50-00-0 formaldehyd 
• 586-38-9 3-Methoxybenzoic acid 
• 99-06-9 3-Carboxyphenol 
• 4741-62-2 5-methoxyisobenzofuran-1(3H)-one 
• 28281-76-7 5-methoxyisobenzofuran-1,3-dione 

Downstream Products

• 4741-63-3 6-methoxyphthalide 
• 4741-62-2 5-methoxyisobenzofuran-1(3H)-one 
• 6500-51-2 4-methoxybenzene-1,2-dicarbaldehyde 
• 36132-96-4 1,2-bis(bromomethyl)-4-methoxybenzene 
• 1333428-89-9 2-methoxy-6-nitronaphthalen-7-yl-methyl 2-(benzamido)acetate 
• 4685-45-4 1,2-bischloromethyl-4-methoxybenzene 
• 36132-97-5 4-methoxy-1,2-benzenediacetonitrile 

Relevant articles and documents

IDO/TDO Inhibitor

A compound of formula (I) given below or a pharmaceutically acceptable salt of the compound is useful as an IDO/TDO inhibitor. Thus, the compound of formula (I) or the pharmaceutically acceptable salt of the compound can be used as, for example, a therapeutic agent for a disease or a disorder selected from tumor, infectious disease, neurodegenerative disorder, cataract, organ transplant rejection, autoimmune disease, postoperative cognitive impairment, and disease related to women's reproductive health [in the following formula (I), ring A represents an aromatic ring, an aliphatic ring, a heterocyclic ring, or a condensed ring of two or more rings selected from an aromatic ring, an aliphatic ring and a heterocyclic ring; X, R1 and R2 represent a substituent on a ring atom constituting ring A; m represents an integer of 0 to 6; X represents, for example, a halogen atom; and R1 and R2 are the same or different and are selected from, for example, the group consisting of groups of formula (a) or formula (b); and in the following formula (a) and formula (b), Y is selected from the group consisting of O, S, and Se, Z is selected from the group consisting of O, S, and Se, n represents an integer of 1 to 8, r represents an integer of 1 to 8, s represents an integer of 1 to 8, R4 represents, for example, —C(═NH)—HN2, and R6 represents, for example, a substituted or unsubstituted aryl group].

Synthesis of 1,2-phenylenedimethanols by base-promoted reduction of isobenzofuran-1(3H)-ones with silane

An efficient method for preparation of substituted 1,2-phenylenedimethanols and aliphatic 1,4-diols that are valuable intermediates in organic synthesis, has been developed by the base-promoted reduction of isobenzofuran-1(3H)-ones and γ-lactones with silane under mild conditions. Compared with traditional procedures using stoichiometric amounts of metal hydrides and alkyl reductants, the present method avoids the use of sensitive reagents and is operationally simple and a broad variety of functional groups are tolerated.

Synthesis of benzobicycloheptanones via the trap of photogenerated ketene methide intermediate with olefins

Irradiation of ortho-formyl dienes with UV light led to benzobicycloheptanones in high yields and chemoselectivities via a photogenerated ketene methide/Diels-Alder cascade reaction. The reaction mechanism was proposed to be a [1,5]-H shift process rather than a radical pathway based on control experiments. DFT calculations indicate that the energy of transition states is responsible for the high chemoselectivity observed in this protocol.