3614-38-8

Basic information

• Product Name: 4-(acetylamino)-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
• Synonyms: 4-(acetylamino)-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;Einecs 222-787-1;m-Acetanisidide, 4'-((2-(diethylamino)ethyl)carbamoyl)-
• CAS NO: 3614-38-8
• Molecular Formula: C₁₆H₂₅N₃O₃
• Molecular Weight: 307.388
• EINECS: 222-787-1
• Mol File: 3614-38-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 501.1°C at 760 mmHg
• Flash Point: 256.8°C
• Appearance: /
• Density: 1.111g/cm³
• Vapor Pressure: 3.59E-10mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: 4-(acetylamino)-N-[2-(diethylamino)ethyl]-2-methoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(acetylamino)-N-[2-(diethylamino)ethyl]-2-methoxybenzamide(3614-38-8)
• EPA Substance Registry System: 4-(acetylamino)-N-[2-(diethylamino)ethyl]-2-methoxybenzamide(3614-38-8)

Safety Data

• Hazardous Substances Data: 3614-38-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H25N3O3/c1-5-19(6-2)10-9-17-16(21)14-8-7-13(18-12(3)20)11-15(14)22-4/h7-8,11H,5-6,9-10H2,1-4H3,(H,17,21)(H,18,20)

Upstream product

• 100-36-7 N,N-diethylethylenediamine 
• 27492-84-8 Methyl 4-amino-2-methoxybenzoate 
• 2486-80-8 4-amino-2-methoxybenzoic acid 
• 55304-05-7 4-acetylamino-2-methoxy-benzoic acid 
• 4093-29-2 methyl 4-(acetylamino)-o-anisate 
• 3761-48-6 1112JDO 
• 75-36-5 acetyl chloride 

Downstream Products

• 3761-48-6 1112JDO 
• 864462-60-2 [2-(4-acetylamino-2-methoxy-benzoylamino)-ethyl]-diethyl-methyl-ammonium iodide 
• 947263-67-4 N-(2-(diethylamino)ethyl)-2-methoxy-4-(tosylamino)benzamide 
• 864462-59-9 N-(2-(diethylamino)ethyl)-2-methoxy-4-(mesylamino)benzamide 
• 947263-66-3 4-acetylamino-N-(2-diethylamino-ethyl)-5-iodo-2-methoxy-benzamide 

Relevant articles and documents

Synthesis and evaluation of novel radioiodinated benzamides for malignant melanoma

The imaging potential of a series of [123I]benzamides was studied in mice bearing B16F0 melanoma tumors. Compound [123I]25 exhibited tumor uptake >8 %ID/g at 1 h, while that of [123I]14d and [123I]25 reached a maximum of 9-12 %ID/g at 6 h. Standardized uptake values of [123I]14d were higher than 100 between 24 and 72 h after injection. In haloperidol treated animals, the tumor uptake of [ 123I]14d was not significantly different to controls, while significant reduction of [123I]25 uptake was observed, supporting that [123I]14d uptake relates to melanin interaction, whereas part of the mechanism of [123I]25 uptake is related to its σ1-receptor affinity. Benzamides 14d and 25, which display rapid and high tumor uptake, appear to be promising imaging agents for melanoma detection, while 14d, which displays a long lasting and high melanoma/nontarget ratio, is more suitable for evaluation as a potential radiotherapeutic.