36146-27-7

Basic information

• Product Name: 3-Phenylisonicotinonitrile
• Synonyms: 3-Phenylisonicotinonitrile
• CAS NO: 36146-27-7
• Molecular Formula: C₁₂H₈N₂
• Molecular Weight: 180.20532
• Mol File: 36146-27-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Phenylisonicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Phenylisonicotinonitrile(36146-27-7)
• EPA Substance Registry System: 3-Phenylisonicotinonitrile(36146-27-7)

Safety Data

• Hazardous Substances Data: 36146-27-7(Hazardous Substances Data)

Upstream product

• 100-48-1 pyridine-4-carbonitrile 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 1008-88-4 3-phenylpyridine 
• 7677-24-9 trimethylsilyl cyanide 
• 98-80-6 phenylboronic acid 
• 108-86-1 bromobenzene 
• 94-36-0 dibenzoyl peroxide 

Downstream Products

• 1335110-60-5 3,5-diphenylpyridine-4-carbonitrile 

Relevant articles and documents

Silver-Catalyzed Minisci Reactions Using Selectfluor as a Mild Oxidant

A new method for silver-catalyzed Minisci reactions using Selectfluor as a mild oxidant is reported. Heteroarenes and quinones both participate in radical C-H alkylation and arylation from a variety of carboxylic and boronic acid radical precursors. Several oxidatively sensitive and highly reactive radical species are successful, providing structures that are challenging to access by other means.

Pyridine derivatives directly aromatise process (by machine translation)

The invention relates to the technical field of preparation processes of aromatic pyridine derivatives, and in particular relates to a direct aromatization process of a pyridine derivative. The process comprises the following flows of adding the pyridine derivative, arylboronic acid, ferrite and trifluoroacetic acid to a flask in sequence, stirring the mixture uniformly at room temperature, adding persulfate, continuing stirring, and filtering, extracting, concentrating and separating the obtained product after reaction is completed, thus obtaining the aromatized pyridine derivative. The direct aromatization process has the beneficial effects that ferrite is adopted as a catalyst, persulfate is adopted as an oxidant, arylboronic acid is promoted to generate aryl free radicals in the persulfate radical and ferrous oxide ion reaction process, and the aryl free radicals are added to the pyridine derivative, thus obtaining the corresponding product; the direct aromatization process is relatively low in production cost and relatively high in reaction yield, and is suitable for popularization and use.

Scope and limitation for FeSO4-mediated direct arylation of heteroarenes with arylboronic acids and its synthetic applications

FeSO4-mediated direct arylation of heteroarenes with arylboronic acids in the presence of K2S2O8 has been developed. A slow addition of an aqueous solution of an iron complex was crucial in the arylation. Scope and limitation of the heteroarenes and arylboronic acids are discussed. Furthermore, the direct arylation was applied to the formal total synthesis botryllazine B and sodium channel inhibitor.