36155-85-8

Basic information

• Product Name: 5-Chlorothiophene-3-carbo...
• Synonyms: 5-Chlorothiophene-3-carbo...;5-chlorothiophene-3-carbaldehyde;5-Chlorothiophene-3-carboxaldehyde
• CAS NO: 36155-85-8
• Molecular Formula: C₅H₃ClOS
• Molecular Weight: 146.6
• Mol File: 36155-85-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 208.8±20.0 °C(Predicted)
• Appearance: /
• Density: 1.429±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 5-Chlorothiophene-3-carbo...(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chlorothiophene-3-carbo...(36155-85-8)
• EPA Substance Registry System: 5-Chlorothiophene-3-carbo...(36155-85-8)

Safety Data

• Hazardous Substances Data: 36155-85-8(Hazardous Substances Data)

Usage

Uses

5-Chloro-3-thiophenecarboxaldehyde is a useful reagent in the preparation of 2,4-Diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists.

Upstream product

• 73919-87-6 (5-chlorothiophen-3-yl)methanol 
• 498-62-4 3-thiophene carboxaldehyde 

Downstream Products

• 78347-95-2 4-<2-(2'-bromophenyl)ethyl>-2-chlorothiophene 
• 74168-80-2 5-chloro-3-(2-phenylethyl)-2-thiophenecarboxylic acid 
• 78370-87-3 (E)-4-<2-(2'-bromophenyl)ethenyl>-2-chlorothiophene 
• 36157-42-3 2-chlorothiophene-4-carboxylic acid 

Relevant articles and documents

PIPERIDINE-DIONE DERIVATIVES

The invention provides novel compounds having the general formula (I) and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.

2,4-Diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists

Ghrelin, a gut-derived orexigenic hormone, is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R). Centrally administered ghrelin has been shown to cause hunger and increase food intake in rodents. Inhibition of ghrelin actions with ghrelin antibody, peptidyl GHS-R antagonists, and antisense oligonucleosides resulted in weight loss and food intake decrease in rodents. Here we report the effects of GHS-R antagonists, some of which were potent, selective, and orally bioavailable. A structure-activity relationship study led to the discovery of 8a, which was effective in decreasing food intake and body weight in several acute rat studies.

Diamine derivatives

A compound represented by the general formula (1): Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4??(1) wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.