362-86-7

Basic information

• Product Name: 3-(p-fluorophenyl)-3-phenylpropionic acid
• Synonyms: 3-(p-fluorophenyl)-3-phenylpropionic acid;4-Fluoro-β-phenylbenzenepropionic acid;3-(4-fluorophenyl)-3-phenylpropanoic acid(SALTDATA: FREE);3-(4-Fluorophenyl)-3-phenylpropanoic acid
• CAS NO: 362-86-7
• Molecular Formula: C₁₅H₁₃FO₂
• Molecular Weight: 244.2609232
• EINECS: 206-652-4
• Mol File: 362-86-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 359.8°Cat760mmHg
• Flash Point: 171.4°C
• Appearance: /
• Density: 1.212g/cm³
• Vapor Pressure: 8.35E-06mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: 3-(p-fluorophenyl)-3-phenylpropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(p-fluorophenyl)-3-phenylpropionic acid(362-86-7)
• EPA Substance Registry System: 3-(p-fluorophenyl)-3-phenylpropionic acid(362-86-7)

Safety Data

• Hazardous Substances Data: 362-86-7(Hazardous Substances Data)

Usage

Description

3-(p-fluorophenyl)-3-phenylpropionic acid, also known as flurbiprofen, is a nonsteroidal anti-inflammatory drug (NSAID) that possesses analgesic and anti-inflammatory properties. It functions by inhibiting the production of prostaglandins, which are chemicals responsible for pain and inflammation in the body.

Uses

Used in Pharmaceutical Industry:
Flurbiprofen is utilized as an analgesic and anti-inflammatory agent for the treatment of various conditions, including arthritis, menstrual cramps, and other types of pain. It is available in both prescription and over-the-counter forms, making it accessible for a wide range of patients.
Used in Pain Management:
Flurbiprofen serves as an effective pain reliever, targeting the prostaglandins that cause discomfort and inflammation. This makes it a valuable option for individuals seeking relief from various types of pain.
Used in Inflammation Reduction:
Due to its ability to inhibit prostaglandin production, flurbiprofen is also used to reduce inflammation associated with different conditions, providing relief and improving the quality of life for those affected.
It is important to use flurbiprofen as directed and to consult a healthcare professional before using it, especially if you have any underlying health conditions or are taking other medications. While generally well tolerated, it may cause side effects such as gastrointestinal discomfort and an increased risk of cardiovascular events with prolonged use.

InChI:InChI=1/C15H13FO2/c16-13-8-6-12(7-9-13)14(10-15(17)18)11-4-2-1-3-5-11/h1-9,14H,10H2,(H,17,18)

Upstream product

• 395-21-1 1-(4-fluorophenyl)-1-phenylethylene 
• 3495-36-1 cesium formate 
• 140-10-3 (E)-3-phenylacrylic acid 
• 1765-93-1 4-fluoroboronic acid 
• 621-82-9 Cinnamic acid 
• 459-32-5 4-fluorocinnamic acid 
• 98-80-6 phenylboronic acid 
• 462-06-6 fluorobenzene 
• 428-00-2 3-(4-fluoro-phenyl)-3-hydroxy-3-phenyl-propionic acid ethyl ester 
• 19334-70-4 3-Hydroxy-3-phenyl-3-<4-fluor-phenyl>-propionsaeure 
• 100-52-7 benzaldehyde 
• 2025-40-3 ethyl benzylidenecyanoacetate 
• 365-21-9 1-(chlorophenylmethyl)-4-fluorobenzene 
• 390-42-1 (E/Z)-3-(4-fluorophenyl)-3-phenylpropenoic acid 

Downstream Products

• 1026728-00-6 2-(2-{2-[3-(4-fluoro-phenyl)-3-phenyl-propyl]-1H-imidazol-4-yl}-ethyl)-isoindole-1,3-dione 
• 80273-08-1 Lu 17-123 
• 104087-10-7 1-chloro-4-(4-flurophenyl)indan 
• 80272-55-5 cis-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-ol 
• 374724-94-4 3-(4-fluorophenyl)-3-phenylpropan-1-ol 
• 85662-85-7 3-(4-fluorophenyl)-2,3-dihydro-1H-indene-1-one 

Relevant articles and documents

Covalent organic framework supported Pd(II)-catalyzed conjugate additions of arylboronic acids to α,β-unsaturated carboxylic acids

A palladium(II)-coordinated covalent organic framework (Pd(II)@COF) was mechanochemically synthesized from [2,2′-bipyridine]-5,5′-diamine (Bpy) and 1,3,5-triformylphloroglucinol (Tp), which was demonstrated as a catalyst for conjugate addition of arylboronic acids to unreactive α,β-unsaturated carboxylic acids in aqueous media (water/acetone = 1:1). Modest to good yields were obtained for most substrates, and studies on the catalyst recyclability showed that the heterogeneous catalyst gave >80% yields in the first 4 cycles. This research broadens the application of COFs supported catalysis and gave a new option for Pd(II)-catalysis.

Synthesis method of succinic acid derivative or 3 -arylpropionic acid (by machine translation)

The invention discloses a synthesis method of a succinic acid derivative or 3 -arylpropionic acid, which comprises the following steps: adding a base in a drying reaction tube and CO removing CO. 2 The reaction is carried out under the irradiation of visible light, the reaction is carried out under visible light irradiation, and then separation and purification are carried out to obtain the butanedioic acid derivative or 3 -arylpropionic acid product; the base comprises sodium tert-butoxide, potassium tert-butoxide, lithium tert-butyl alcohol and 4 - potassium carbonate; and the reaction substrate comprises an acrylate compound or an aryl vinyl compound. CO can be induced by visible light. 2 The scheme provided by the invention is mild in reaction condition and wide in reaction 3 - substrate selectivity, and the reaction substrate is wide in selectivity, the raw materials are cheap and easily available, and the method has a good industrial application prospect. (by machine translation)

Pd(II)/Bipyridine-Catalyzed Conjugate Addition of Arylboronic Acids to α,β-Unsaturated Carboxylic Acids. Synthesis of β-Quaternary Carbons Substituted Carboxylic Acids

Pd(II)/bipyridine-catalyzed conjugate addition of arylboronic acids to α,β-unsaturated carboxylic acids (including β,β-disubstituted acrylic acids) was developed and optimized, which provided a mild and convenient method for the highly challenging synthesis of β-quaternary carbons substituted carboxylic acids.