3621-99-6

Basic information

• Product Name: 2-(METHYLTHIO)-6-NITRO-1,3-BENZOTHIAZOLE
• Synonyms: BUTTPARK 94\04-95;2-(METHYLTHIO)-6-NITRO-1,3-BENZOTHIAZOLE;2-(METHYLTHIO)-6-NITROBENZOTHIAZOLE;2-(Methylsulphanyl)-6-nitro-1,3-benzothiazole, 2-(Methylmercapto)-6-nitro-1,3-benzothiazole;2-methylsulfanyl-6-nitro-1,3-benzothiazole
• CAS NO: 3621-99-6
• Molecular Formula: C₈H₆N₂O₂S₂
• Molecular Weight: 226.28
• Mol File: 3621-99-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 134 °C
• Boiling Point: 395.4°Cat760mmHg
• Flash Point: 192.9°C
• Appearance: /
• Density: 1.51g/cm³
• Vapor Pressure: 4.22E-06mmHg at 25°C
• Refractive Index: 1.718
• CAS DataBase Reference: 2-(METHYLTHIO)-6-NITRO-1,3-BENZOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(METHYLTHIO)-6-NITRO-1,3-BENZOTHIAZOLE(3621-99-6)
• EPA Substance Registry System: 2-(METHYLTHIO)-6-NITRO-1,3-BENZOTHIAZOLE(3621-99-6)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 3621-99-6(Hazardous Substances Data)

Usage

General Description

2-(Methylthio)-6-nitro-1,3-benzothiazole is a chemical compound with the molecular formula C8H6N2OS2. It is a yellow solid that is used as a fluorescent dye and in the manufacturing of photographic materials. 2-(METHYLTHIO)-6-NITRO-1,3-BENZOTHIAZOLE is also used as a reagent in organic synthesis for the preparation of various pharmaceuticals and agrochemicals. Additionally, 2-(Methylthio)-6-nitro-1,3-benzothiazole has shown potential as an antimicrobial agent. Due to its unique properties, this chemical compound has a wide range of industrial and scientific applications.

InChI:InChI=1/C8H6N2O2S2/c1-13-8-9-6-3-2-5(10(11)12)4-7(6)14-8/h2-4H,1H3

Upstream product

• 4845-58-3 2-mercapto-6-nitrobenzothiazole 
• 74-88-4 methyl iodide 
• 140-89-6 potassium ethyl xanthogenate 
• 149-30-4 2-Mercaptobenzothiazole 
• 121579-06-4 bis(6-nitrobenzo[d]thiazol-2-yl)disulfide 
• 2407-11-6 2-chloro-6-nitrobenzothiazole 
• 149-30-4 2-thioxo-3H-1,3-benzothiazole 
• 77-78-1 dimethyl sulfate 
• 4845-58-3 6-nitrobenzo[d]thiazole-2(3H)-thione 
• 615-22-5 2-methylmercaptobenzothiazole 

Downstream Products

• 55514-14-2 3-methyl-2-(methylthio)benzothiazolium tosylate 
• 21554-41-6 2-(methylsulfonyl)-6-nitrobenzo[d]thiazole 
• 3779-13-3 2-(methylsulfinyl)-6-nitrobenzo[d]thiazole 
• 2458-05-1 3-methyl-2-methylsulfanyl-6-nitro-benzothiazolium; methyl sulfate 
• 34976-39-1 Tioxacin 
• 28620-12-4 6-nitro-2(3H)-benzothiazolone 
• 775313-32-1 N-acetyl-sulfanilic acid-(2-methylsulfanyl-benzothiazol-6-ylamide) 

Relevant articles and documents

Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine

Proteome profiling by activated esters identified >9000 ligandable lysines but they are limited as covalent inhibitors due to poor hydrolytic stability. Here we report our efforts to design and discover a new series of tunable amine-reactive electrophiles (TAREs) for selective and robust labeling of lysine. The major challenges in developing selective probes for lysine are the high nucleophilicity of cysteines and poor hydrolytic stability. Our work circumvents these challenges by a unique design of the TAREs that form stable adducts with lysine and on reaction with cysteine generate another reactive electrophiles for lysine. We highlight that TAREs exhibit substantially high hydrolytic stability as compared to the activated esters and are non-cytotoxic thus have the potential to act as covalent ligands. We applied these alternative TAREs for the intracellular labeling of proteins in different cell lines, and for the selective identification of lysines in the human proteome on a global scale.

Radical Fluoroalkylation of Isocyanides with Fluorinated Sulfones by Visible-Light Photoredox Catalysis

The radical fluoroalkylation of isocyanides with fluorinated sulfones is enabled by visible-light photoredox catalysis. A wide range of readily available mono-, di-, and trifluoromethyl heteroaryl sulfones can thus be used as efficient radical fluoroalkylation reagents under mild conditions. This method not only describes a new synthetic application of fluorinated sulfones, but also provides a new route to fluoroalkyl radicals.

PROLINE DERIVATIVES AND USE THEREOF AS DRUGS

The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.