36241-14-2Relevant articles and documents
Synthesis of optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids
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, (2008/06/13)
The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of pla
Optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids and pharmaceutical use thereof
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, (2008/06/13)
The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of pla
7-Oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives, their use and preparation
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, (2008/06/13)
7-Oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives of formula (I): STR1 (in which:) R1 represents a hydrogen atom or an optionally substituted alkyl group; X represents an oxy group, a thio group, a sulphinyl group or a sulphonyl group; A represents a bivalent for trivalent saturated aliphatic hydrocarbon group; p is 1 (when A is bivalent) or 2 (when A is trivalent); R2 represents an azido, nitro or cyano group or one of the groups of formula STR2 m and n are the same or different and each is 0 or 1; R represents an amidino group or a group of formula R4, --N(R4)2 or --YR4, B represents a group of formula STR3 D represents a group of formula STR4 (provided that, where m and n are both 1, the groups represented by B and D must be different); R4 represents a hydrogen atom or an alkyl group and, where there are 2 or more groups represented by R4, they may be the same or different, and Y represents an oxygen atom or a sulphur atom; and R3 represents a carboxy group or a protected carboxy group) and pharmaceutically acceptable salts thereof are valuable antibiotics and may be prepared by a process which includes heating a corresponding phosphorus-ylide compound.