362509-18-0

Basic information

• Product Name: 4-(3-chloro-4-fluoroanilino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine
• Synonyms: 4-(3-chloro-4-fluoroanilino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine
• CAS NO: 362509-18-0
• Molecular Weight: 333.817
• Mol File: 362509-18-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(3-chloro-4-fluoroanilino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-chloro-4-fluoroanilino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine(362509-18-0)
• EPA Substance Registry System: 4-(3-chloro-4-fluoroanilino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine(362509-18-0)

Safety Data

• Hazardous Substances Data: 362509-18-0(Hazardous Substances Data)

Upstream product

• 40493-18-3 4-chloro-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 4506-71-2 ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 

Relevant articles and documents

Synthesis and biological evaluation of di-aryl urea derivatives as c-Kit inhibitors

Inhibition of receptor tyrosine kinases (RTKs) continued to be a successful approach for the treatment of many types of human cancers and many potent small molecules kinase inhibitors have been discovered the last decade. In the present study, we describe

Microwave-based synthesis of novel thienopyrimidine bioisosteres of gefitinib

A series of novel 2-unsubstituted 4-(substituted)anilinothieno[2,3-d]pyrimidines is synthesized through the chlorination of the corresponding 2-unsubstituted-thieno[2,3-d]-pyrimidin-4-ones, followed by the nucleophilic displacement of the 4-Cl group of 9, with a variety of anilines. All four steps of this synthesis involve microwave irradiation (MWI) and the entire synthesis requires only 2 h.