362609-92-5

Basic information

• Product Name: 3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE
• Synonyms: BENZO[D][1,3]DIOXOLE-5-GLYOXAL HYDRATE;3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE;3,4-METHYLENEDIOXYPHENYLGLYOXAL HYDRATE, 95+%;2-(Benzo[d][1,3]dioxol-5-yl)-2-oxoacetaldehyde hydrate
• CAS NO: 362609-92-5
• Molecular Formula: C₉H₈O₅
• Molecular Weight: 196.16
• Mol File: 362609-92-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE(362609-92-5)
• EPA Substance Registry System: 3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE(362609-92-5)

Safety Data

• Hazardous Substances Data: 362609-92-5(Hazardous Substances Data)

Usage

General Description

3,4-(Methylenedioxy)phenylglyoxal hydrate, also known as Safrole glyoxal, is a chemical compound with the molecular formula C10H10O4. It is a colorless to pale yellow crystalline solid that is soluble in water and organic solvents. 3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE is commonly used in the organic synthesis of various pharmaceutical and agricultural products. It is also used as an intermediate in the synthesis of fragrances and flavoring compounds. Additionally, 3,4-(Methylenedioxy)phenylglyoxal hydrate has been studied for its potential antimicrobial and antifungal properties, making it an important chemical in the field of biomedical research.

Upstream product

• 65709-23-1 3,4-methylenedioxyphenylglyoxal 
• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 

Downstream Products

• 89015-27-0 (R)-α-hydroxyphenylacetic acid iso-propyl ester 
• 53439-96-6 (S)-α-hydroxyphenylacetic acid iso-propyl ester 
• 31197-66-7 isopropyl benzoylformate 

Relevant articles and documents

Catalytic asymmetric Meerwein-Ponndorf-Verley reduction of glyoxylates induced by a chiral N,N′-dioxide/Y(OTf)3 complex

An asymmetric Meerwein-Ponndorf-Verley (MPV) reduction of glyoxylates was for the first time accomplished via an N,N′-dioxide/Y(OTf)3 complex with aluminium alkoxide and molecular sieves (MSs) as crucial additives. A variety of optically active α-hydroxyesters were obtained with excellent results. A possible reaction mechanism was proposed based on the experiments.

A Green and Convenient Route for the Regioselective Synthesis of New Substituted 3-Aryl-5H-indeno[1,2-c]pyridazines as Potential Monoamine Oxidase Type A Inhibitors

Several indeno[1,2-c]pyridazines were efficiently synthesised using the one-pot, three-component reaction of substituted indanones, arylglyoxalmonohydrates, and hydrazine in the presence of 1,5-diazabicyclo[4,3,0]non-5-ene (DBN) in water at room temperature. These substituted 3-aryl indeno[1,2-c]pyridazines can be considered as potential monoamine oxidase type A (MAOA) inhibitors. The advantages of this new strategy are the novelty of the indenopyridazine derivatives, high regioselectivity, use of water as the solvent, no requirement for toxic metal catalysts, and good to excellent yields.

Regiospecific one-pot, combinatorial synthesis of new substituted pyrimido[4,5-c]pyridazines as potential monoamine oxidase inhibitors

New 3-aryl-6-methylpyrimido[4,5-c]pyridazine-5,7(6H ,8H)-diones and 3-aryl-6-ethyl-7-thioxo-7,8-dihydropyrimido[4,5- c]pyridazin-5(6H)-ones were efficiently synthesized via a regiospecific one-pot reaction of N -methylbarbituric acid and N -ethyl-2-thiobarbituric acid with various arylglyoxal monohydrates in the presence of hydrazine dihydrochloride in ethanol at 50°C. The target compounds were obtained in high yields and were regioisomerically pure after recrystallization. These new heterocycles may act as potential MAOB inhibitors.