362665-56-3 Usage
Description
Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-, also known as Pitolisant, is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor. It is a synthetic compound with a unique chemical structure that allows it to selectively target the histamine H3 receptor, making it a promising pharmaceutical candidate for various applications.
Uses
Used in Pharmaceutical Industry:
Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]is used as a therapeutic agent for the treatment of patients with narcolepsy, a chronic neurological disorder characterized by excessive daytime sleepiness, cataplexy, disturbed nocturnal sleep, hypnagogic hallucinations, and sleep paralysis. As a selective inverse agonist at the histamine H3 receptor, Pitolisant modulates the activity of histamine neurons in the brain, leading to an increase in wakefulness and a reduction in sleepiness.
In addition to its primary use in narcolepsy treatment, Pitolisant may also have potential applications in other areas of medicine, such as the treatment of other sleep disorders, cognitive disorders, or even as an adjunct therapy for certain psychiatric conditions. However, further research and clinical trials are needed to fully explore and validate these potential applications.
Check Digit Verification of cas no
The CAS Registry Mumber 362665-56-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,2,6,6 and 5 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 362665-56:
(8*3)+(7*6)+(6*2)+(5*6)+(4*6)+(3*5)+(2*5)+(1*6)=163
163 % 10 = 3
So 362665-56-3 is a valid CAS Registry Number.
362665-56-3Relevant articles and documents
1 - [3 - [3 - (4-chlorophenyl) propoxy] propyl]-piperidine hydrochloride method for the preparation of (by machine translation)
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, (2017/03/08)
The invention relates to a 1 - [3 - [3 - (4-chlorophenyl) propoxy] propyl]-piperidine hydrochloride preparation method, the steps of : (1) the piperidine and 1,3-dihalogenated propane in the water-soluble polar non-protonic solvent, under the action of a basic compound, condensation reaction to obtain N-(3-halo-propyl) piperidine ; (2) N-(3- halogen propyl ) piperidine and 3 - (4-chlorophenyl) propyl alcohol in the solvent, under the action of an alkaline compound to ether, to obtain compound 1 - [3 - [3 - (4-chlorophenyl) propoxy] propyl]-piperidine ; (3) 1 - [3 - [3-4-chlorophenyl) propoxy] propyl]-piperidine and HCl reaction product is obtained. Process step of this invention is simple, the operation is convenient, easy availability of raw materials, the price is cheap, the product prepared in high yield, high purity, low cost, is suitable for industrial production. (by machine translation)
MONOHYDROCHLORIDE SALT OF 1- [3- [3- (4-CHLOROPHENYL) PROPOXY] PROPYL] -PIPERIDINE
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Page/Page column 8, (2008/06/13)
New salt of 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine. The invention relates to new crystalline 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine monohydrochloride, the respective manufacture and methods of use, and compositions containing such a compound.
