36282-26-5

Basic information

• Product Name: 2-Bromo-4-fluorobenzonitrile
• Synonyms: 2-BROMO-4-FLUOROBENZONITRILE;2-Bromo-4-fluorobenzonitrile 98%;2-Bromo-4-fluorobenzonitrile98%;Benzonitrile, 2-broMo-4-fluoro-;Bromo-4-fluorobenzonitrile
• CAS NO: 36282-26-5
• Molecular Formula: C₇H₃BrFN
• Molecular Weight: 200.01
• EINECS: 252-949-7
• Product Categories: Fluorobenzene;Aromatic Nitriles;Nitrile;Bromine Compounds;Fluorine Compounds;Nitriles;Aryl Fluorinated Building Blocks;Building Blocks;C7;Chemical Synthesis;Fluorinated Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks
• Mol File: 36282-26-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 77-78°C
• Boiling Point: 262.4 °C at 760 mmHg
• Flash Point: 112.5 °C
• Appearance: White powder
• Density: 1.69 g/cm³
• Vapor Pressure: 0.0109mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• BRN: 1940597
• CAS DataBase Reference: 2-Bromo-4-fluorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-fluorobenzonitrile(36282-26-5)
• EPA Substance Registry System: 2-Bromo-4-fluorobenzonitrile(36282-26-5)

Safety Data

• Hazard Codes: T,Xi,Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-36/37/39-36/37-26-9
• RIDADR: 3439
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 36282-26-5(Hazardous Substances Data)

Usage

Chemical Properties

Off-white to light yellow powder

InChI:InChI=1/C7H3BrFN/c8-7-3-6(9)2-1-5(7)4-10/h1-3H

Upstream product

• 1309606-40-3 2-bromo-4-fluorobenzaldehyde oxime 
• 59142-68-6 2-bromo-4-fluorobenzaldehyde 
• 1194-02-1 4-fluorobenzonitrile 
• 1006-41-3 2-bromo-4-fluorobenzoic acid 
• 1006-40-2 2-bromo-4-fluorobenzamide 

Downstream Products

• 36282-27-6 2'-Brom-4'-fluor-2-phenylacetophenon 
• 1008520-62-4 4-(3-Acetyl-2,4-dimethyl-pyrrol-1-yl)-2-bromo-benzonitrile 
• 908111-35-3 2-bromo-4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzonitrile 
• 908111-45-5 2-bromo-4-(6,6-dimethyl-4-oxo-3-difluoromethyl-4,5,6,7-tetrahydro-indazol-1-yl)-benzonitrile 
• 1173111-59-5 2-bromo-4-(2,3,6,6-tetramethyl-4-oxo-4,5,6,7-tetrahydro-indol-1-yl)-benzonitrile 
• 1173111-58-4 2-bromo-4-(6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-indol-1-yl)-benzonitrile 
• 917002-14-3 2-bromo-4-(3-methyl-4-oxo-4,5,6,7-tetrahydro-indol-1-yl)-benzonitrile 
• 930572-43-3 4-(3-acetyl-indol-1-yl)-2-bromo-benzonitrile 
• 289038-14-8 2-bromo-4-fluorobenzylamine hydrochloride 
• 1293323-83-7 (2-bromo-4-fluorobenzyl)(cyclohex-2-enyl)carbamic acid tert-butyl ester 
• 1415599-58-4 (2R)-2-amino-N-[4-[(3,3-dimethyl-1H-isobenzofuran-5-yl)oxy]phenyl]-2-methyl-butanamide 
• 1415598-75-2 [2-bromo-4-[tert-butyl(dimethyl)silyl]oxyphenyl]methanol 
• 609347-96-8 2-bromo-4-(tert-butyl-dimethyl-silanyloxy)-benzaldehyde 
• 1415598-76-3 2-[5-[tert-butyl(dimethyl)silyl]oxy-2-(hydroxymethyl)phenyl]propan-2-ol 

Relevant articles and documents

Thiocyanate radical mediated dehydration of aldoximes with visible light and air

We developed a new means of activating aldoximes by an in situ generated thiocyanate radical from ammonium thiocyanate and molecular oxygen at room temperature. With a catalytic amount of organic dye aizenuranine as the photocatalyst, the dehydration of aldoximes proceeds smoothly under visible light irradiation, providing a simple to handle, excellent functional group tolerance, and metal-free protocol for a wide range of nitriles.

A radical cyclization cascade of 2-alkynylbenzonitriles with sodium arylsulfinates

A convenient radical cyclization cascade procedure for the construction of sulfonated indenones from 2-alkynylbenzonitriles and sodium arylsulfinates has been explored under mild reaction conditions. The present methodology offers a low-cost and operationally straightforward approach to synthesizing various sulfonated indenones in moderate to good yields by simple use of cheap sodium persulfate as an oxidant and environmentally benign water as a co-solvent.

Palladium-Catalyzed Ring-Forming Aminoalkenylation of Alkenes with Aldehydes Initiated by Intramolecular Aminopalladation

A palladium-catalyzed aminopalladation reaction followed by nucleophilic addition with aldehydes and dehydration is described. This direct and operationally simple procedure provides a rapid and reliable approach to a wide range of functionalized tetrahydroisoquinolines with high selectivity. Mechanistic studies disclosed that the nucleophilic addition, performed via a highly ordered transition-state, is the turnover-limiting step in which the inherent β-hydride elimination of the key Csp3?Pd species was controlled by the confined conformation and the nucleophilicity of the Csp3?Pd bond was enhanced by the strong electron-donating effect of the nitrogen atom.