363152-44-7

Basic information

• Product Name: (S)-4-Nitro-3-phenyl-1-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-butan-1-one
• Synonyms: (S)-4-Nitro-3-phenyl-1-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-butan-1-one
• CAS NO: 363152-44-7
• Molecular Weight: 417.621
• Mol File: 363152-44-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-4-Nitro-3-phenyl-1-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-Nitro-3-phenyl-1-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-butan-1-one(363152-44-7)
• EPA Substance Registry System: (S)-4-Nitro-3-phenyl-1-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-butan-1-one(363152-44-7)

Safety Data

• Hazardous Substances Data: 363152-44-7(Hazardous Substances Data)

Upstream product

• 102-96-5 (2-nitroethenyl)benzene 
• 204577-67-3 (1R)-2-endo-acetyl-2-exo-(trimethylsilyloxy)-1,7,7-trimethylbicyclo[2.2.1]heptane 

Downstream Products

• 852051-16-2 (S)-(-)-4-nitro-3-phenylbutanoic acid 
• 464-49-3 (1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one 
• 363152-46-9 (S)-1-((1R,2R,4R)-2-Hydroxy-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl)-4-nitro-3-phenyl-butan-1-one 

Relevant articles and documents

Diastereoselective Michael reactions of (1R)-(+)-camphor methyl ketone enolates with nitro olefins

The reaction of the sodium enolate of the methyl ketone 2 with a range of nitro olefins proceeds readily to give the corresponding Michael adducts in good yields and diastereoselectivities. Subsequent oxidative cleavage of the acyloin moiety provides γ-nitroalkanoic acids along with (1R)-(+)-camphor, the chiral auxiliary of the process, which can be recovered and reused.