36331-57-4

Basic information

• Product Name: phenylmethanesulfonohydrazide
• Synonyms: phenylmethanesulfonohydrazide;1-phenylmethanesulfonohydrazide;NSC109916
• CAS NO: 36331-57-4
• Molecular Formula: C₇H₁₀N₂O₂S
• Molecular Weight: 186.2315
• Mol File: 36331-57-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 360.4°Cat760mmHg
• Flash Point: 171.8°C
• Appearance: /
• Density: 1.337g/cm³
• Vapor Pressure: 2.23E-05mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: phenylmethanesulfonohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: phenylmethanesulfonohydrazide(36331-57-4)
• EPA Substance Registry System: phenylmethanesulfonohydrazide(36331-57-4)

Safety Data

• Hazardous Substances Data: 36331-57-4(Hazardous Substances Data)

Usage

General Description

Phenylmethanesulfonohydrazide, also known as benzenesulfonyl hydrazide, is a chemical compound with the formula C7H9N3O2S. It is commonly used as a reagent in organic synthesis, particularly for the selective reduction of carbonyl compounds to their corresponding alcohols. Phenylmethanesulfonohydrazide can also be used as a curing agent for epoxy resins and as a stabilizer for polymers. It is known for its ability to inhibit the formation of nitrosamines, which are potential carcinogens, in certain food products. Additionally, it has been researched for its potential applications in pharmaceuticals and cosmetics. Due to its versatile and valuable properties, phenylmethanesulfonohydrazide is an important chemical in various industries.

InChI:InChI=1/C7H10N2O2S/c8-9-12(10,11)6-7-4-2-1-3-5-7/h1-5,9H,6,8H2

Upstream product

• 329-98-6 phenylmethylsulphonyl fluoride 
• 1939-99-7 benzenesulfonyl chloride 

Downstream Products

• 1244620-36-7 C₂₀H₁₈N₂O₂S 
• 633291-96-0 3-(benzylsulfanyl)-1H-indole 
• 92256-05-8 2-Benzylsulfonyl-1-benzyl-hydrazin 
• 17075-10-4 phenylmethanesulfonyl bromide 
• 20474-37-7 benzylsulfonyl azide 
• 4403-73-0 benzylsulfinic acid 
• 124790-91-6 C₁₀H₁₆N₂O₄S₂ 
• 3112-90-1 benzyl-methyl sulfone 

Relevant articles and documents

Dual Roles of Rongalite: Reductive Coupling Reaction to Construct Thiosulfonates Using Sulfonyl Hydrazides

A tunable and practical transformation of structurally diverse sulfonyl hydrazides into thiosulfonates in the presence of Rongalite (NaHSO 2·CH 2O) was developed. Transition-metal-free conditions, operational simplicity, and readily available reagents are the striking features of this protocol. It is the first example for the synthesis of thiosulfonates using sulfonyl hydrazides with the assistance of reductant. Additionally, the mechanistic studies revealed that this transformation probably undergoes via a reducing-coupling pathway.

TBAB-catalyzed 1,6-conjugate sulfonylation of paraquinone methides: A highly efficient approach to unsymmetrical gem-diarylmethyl sulfones in water ?

A highly efficient sulfonylation of para-quinone methides with sulfonyl hydrazines in water has been developed on the basis of the mode involving a tetrabutyl ammonium bromide (TBAB)-promoted sulfa-1,6-conjugated addition pathway. This reaction provides a green and sustainable method to synthesize various unsymmetrical diarylmethyl sulfones, showing good functional group tolerance, scalability, and regioselectivity. Further transformation of the resulting diarylmethyl sulfones provides an efficient route to some functionalized molecules.

An Alternative Metal-Free Aerobic Oxidative Cross-Dehydrogenative Coupling of Sulfonyl Hydrazides with Secondary Phosphine Oxides

An alternative metal-free, efficient and practical approach for the preparation of phosphinothioates is established via the aerobic oxidative cross-dehydrogenative coupling (CDC) of sulfonyl hydrazides with secondary phosphine oxides catalyzed by tetrabutylammonium iodide (TBAI) in the presence of atmospheric oxygen. The strategy provides an array of diverse phosphinothioates in good to excellent yields. Furthermore, two representative bioactive molecules are synthesized on up to gram scale by utilizing this method.