36372-77-7

Basic information

• Product Name: 1,4,5-TRIPHENYL-1H-PYRAZOLE
• Synonyms: 1,4,5-TRIPHENYL-1H-PYRAZOLE
• CAS NO: 36372-77-7
• Molecular Formula: C₂₁H₁₆N₂
• Molecular Weight: 296.37
• Product Categories: pharmacetical
• Mol File: 36372-77-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 443 °C at 760 mmHg
• Flash Point: 221.7 °C
• Appearance: /
• Density: 1.08 g/cm³
• Vapor Pressure: 1.25E-07mmHg at 25°C
• Refractive Index: 1.624
• CAS DataBase Reference: 1,4,5-TRIPHENYL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,5-TRIPHENYL-1H-PYRAZOLE(36372-77-7)
• EPA Substance Registry System: 1,4,5-TRIPHENYL-1H-PYRAZOLE(36372-77-7)

Safety Data

• Hazardous Substances Data: 36372-77-7(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic compound

Structure

Contains a pyrazole ring and three phenyl groups attached at different positions

Medicinal chemistry

Synthesis of various pharmaceuticals and bioactive compounds

Coordination chemistry

Used as a ligand

Material development

Potential applications in organic electronics and optoelectronics

Biological activities

a. Antimicrobial properties
b. Antifungal properties

InChI:InChI=1/C21H16N2/c1-4-10-17(11-5-1)20-16-22-23(19-14-8-3-9-15-19)21(20)18-12-6-2-7-13-18/h1-16H

Upstream product

• 41841-06-9 3,3-dimethoxy-1,2-diphenylpropan-1-one 
• 64-19-7 acetic acid 
• 100-63-0 phenylhydrazine 
• 451-40-1 phenyl benzyl ketone 
• 50-00-0 formaldehyd 
• 80967-26-6 1,5-diphenyl-3-(methylthio)-1H-pyrazole 
• 1296269-72-1 4-iodo-3-(methylthio)-1,5-diphenyl-1H-pyrazole 
• 98-80-6 phenylboronic acid 
• 1296269-71-0 4-bromo-3-(methylthio)-1,5-diphenyl-1H-pyrazole 
• 701980-96-3 C₂₅H₂₆N₂ 
• 59-88-1 phenylhydrazine hydrochloride 
• 89959-83-1 1,3-diphenyl-2,3-bis(tosyloxy)-1-oxopropane 
• 62-53-3 aniline 
• 309297-09-4 4,5-bis(2-iodophenyl)-1-phenylpyrazole 

Downstream Products

• 65480-21-9 1-Phenylphenanthro[9,10-d]pyrazole 
• 7189-13-1 1,3,4,5-tetraphenyl-1H-pyrazole 

Relevant articles and documents

Regioselective rapid analog synthesis of 1,3-(or 1,5-)diphenyl-4-aryl/ heteroaryl-5-(or 3-)(methylthio)pyrazoles via Suzuki cross-coupling

Regioselective routes for the synthesis of 1,3-(or 1,5-)diphenyl-4-aryl/ heteroaryl-5-(or 3-)(methylthio)pyrazoles via Suzuki cross-coupling of 4-bromo (or 4-iodo)-1,3-(or 1,5-)diphenyl-5-(or 3-)(methylthio)pyrazoles have been reported.

The chemistry of α,β-ditosyloxyketones: new and convenient route for the synthesis of 1,4,5-trisubstituted pyrazoles from α,β-chalcone ditosylates

The reaction of α,β-chalcone ditosylates with various reagents such as phenylhydrazine hydrochloride, semicarbazide hydrochloride and thiosemicarbazide in suitable conditions leads to 1,2-aryl shift, thereby providing a novel route for the synthesis of 1,4,5-trisubstituted pyrazoles.

A straightforward synthetic pathway to phenanthro[9,10-d]heterocycles

A series of new 4,5-o,o-bis(haloaryl)pyrazoles was regioselectively prepared by a tandem amine exchange/heterocyclization. The intramolecular Stille-type biaryl coupling of the so-obtained pyrazole derivatives and previously prepared diarylisoxazoles led with high overall yields to the isolation of new phenanthro[9,10-d]pyrazoles and phenanthro[9,10- d]isoxazoles, respectively. The formation of dehalogenation products was efficiently avoided by use of heavy-wall pressure tubes.