364057-81-8

Basic information

• Product Name: 1-(4-methoxybenzylidene)-2-[4-(4-fluorophenyl)thiazol-2-yl]hydrazine
• Synonyms: 1-(4-methoxybenzylidene)-2-[4-(4-fluorophenyl)thiazol-2-yl]hydrazine
• CAS NO: 364057-81-8
• Molecular Weight: 327.382
• Mol File: 364057-81-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-methoxybenzylidene)-2-[4-(4-fluorophenyl)thiazol-2-yl]hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxybenzylidene)-2-[4-(4-fluorophenyl)thiazol-2-yl]hydrazine(364057-81-8)
• EPA Substance Registry System: 1-(4-methoxybenzylidene)-2-[4-(4-fluorophenyl)thiazol-2-yl]hydrazine(364057-81-8)

Safety Data

• Hazardous Substances Data: 364057-81-8(Hazardous Substances Data)

Upstream product

• 4334-74-1 4-methoxybenzylidene thiosemicarbazone 
• 456-04-2 2-Chloro-4'-fluoroacetophenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 82100-92-3 1-(4-(4-fluorophenyl)thiazol-2-yl) hydrazine 
• 1629144-29-1 2-phenoxy-4-(4-fluorophenyl)thiazole 

Relevant articles and documents

2,4- and 2,5-disubstituted arylthiazoles: Rapid synthesis by C-H coupling and biological evaluation

Life-threatening infections caused by bacteria that have developed resistance to common antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA), have become a serious problem in hospitals and other areas all over the world. Thus, the development of an effective class of antibiotics against these bacteria is an urgent subject. Herein, we report a step-economical and diversity-oriented synthesis of a series of 2-arylidenehydrazinyl-4- arylthiazole and 2-arylidenehydrazinyl-5-arylthiazole analogues that utilizes C-H coupling methodologies. A library of 54 new congeners were synthesized and tested for their biological potential. Moreover, new knowledge regarding the structure-activity relationships (SARs) of these heterobiaryl compounds was collected. Copyright