364064-30-2Relevant articles and documents
Iodine-catalyzed efficient conjugate addition of pyrroles to α,β-unsaturated ketones
Das, Biswanath,Chowdhury, Nikhil,Damodar, Kongara
, p. 2867 - 2870 (2007)
Iodine was used as a catalyst for the conjugate addition of pyrroles to α,β-unsaturated ketones at room temperature. Mono- and dialkylated products were obtained by using equimolar amounts of the reactants. However, the use of excess enones afforded only
Ruthenium-catalyzed functionalization of pyrroles and indoles with propargyl alcohols
Thies, Nora,Hrib, Cristian G.,Haak, Edgar
supporting information; experimental part, p. 6302 - 6308 (2012/06/18)
Several ruthenium-catalyzed atom-economic transformations of propargyl alcohols with pyrroles or indoles leading to alkylated, propargylated, or annulated heteroaromatics are reported. The mechanistically distinct reactions are catalyzed by a single ruthenium(0) complex containing a redox-coupled dienone ligand. The mode of activation regarding the propargyl alcohols determines the reaction pathway and depends on the alcohols' substitution pattern. Secondary substrates form alkenyl complexes by a 1,2-hydrogen shift, whereas the transformation of tertiary substrates involves allenylidene intermediates. 1-Vinyl propargyl alcohols are converted by a cascade allylation/cyclization sequence. The environmentally benign processes are of broad scope and allow the selective synthesis of highly functionalized pyrroles and indoles generating water as the only waste product. Copyright
Iron salt-cataltzed multipoint alkylation of pyrrole with vinyl ketones
Kawatsura, Motoi,Fujiwara, Masamune,Uehara, Hiroyuki,Nomura, Shun,Hayase, Shuichi,Itoh, Toshiyuki
, p. 794 - 795 (2008/12/21)
Pyrrole reacted with vinyl ketones in the presence of 3 mol % of iron(II) tetrafluoroborate or alumina-supported iron(III) perchlorate to give multipoint-alkylated products in good yield. Most notably, 4,5-dialkylated 2-acetylpyrrole was obtained in good
