364360-72-5

Basic information

• Product Name: 3-(4-amino-3-fluoro-benzyloxy)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-1H-quinolin-2-one
• CAS NO: 364360-72-5
• Molecular Weight: 583.098
• Mol File: 364360-72-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-amino-3-fluoro-benzyloxy)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-1H-quinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-amino-3-fluoro-benzyloxy)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-1H-quinolin-2-one(364360-72-5)
• EPA Substance Registry System: 3-(4-amino-3-fluoro-benzyloxy)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-1H-quinolin-2-one(364360-72-5)

Safety Data

• Hazardous Substances Data: 364360-72-5(Hazardous Substances Data)

Upstream product

• 253664-14-1 6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-1H-quinolin-2-one 
• 253663-87-5 3-benzenesulfonyl-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-3,4-dihydro-1H-quinolin-2-one 
• 253663-82-0 3-benzenesulfonyl-6-chloro-4-hydroxy-4-trifluoromethyl-3,4-dihydro-1H-quinolin-2-one 
• 253663-85-3 3-benzenesulfonyl-6-chloro-4-trifluoromethyl-1H-quinolin-2-one 
• 253663-53-5 6-chloro-4-(cyclopropylethynyl)-3,4-dihydro-4-(trifluoromethyl)-2(1H)-quinolinone 
• 253668-48-3 2-Bromo-N-[4-chloro-2-(2,2,2-trifluoro-acetyl)-phenyl]-acetamide 
• 154598-53-5 1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone 
• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 253664-16-3 6-chloro-4-cyclopropylethynyl-3-hydroxy-4-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-1H-quinolin-2-one 

Relevant articles and documents

Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors

A series of 4,4-disubstituted quinolinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The C-3 substituted compound 9h displayed improved antiviral activity against clinically significant single (K103N) and double (K103N/L100I) mutant viruses.