36443-15-9

Basic information

• Product Name: 3-diazo-3,4-dihydro-4-oxonaphthalene-2-sulphonyl chloride
• Synonyms: 3-diazo-3,4-dihydro-4-oxonaphthalene-2-sulphonyl chloride
• CAS NO: 36443-15-9
• Molecular Formula: C₈H₁₀O₄
• Molecular Weight: 268.6763
• EINECS: 310-201-8
• Mol File: 36443-15-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: 3-diazo-3,4-dihydro-4-oxonaphthalene-2-sulphonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-diazo-3,4-dihydro-4-oxonaphthalene-2-sulphonyl chloride(36443-15-9)
• EPA Substance Registry System: 3-diazo-3,4-dihydro-4-oxonaphthalene-2-sulphonyl chloride(36443-15-9)

Safety Data

• Hazardous Substances Data: 36443-15-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H5ClN2O3S/c11-17(15,16)8-5-6-3-1-2-4-7(6)10(14)9(8)13-12/h1-5H

Upstream product

• 3658-77-3 furaneol 
• 75-36-5 acetyl chloride 

Relevant articles and documents

Synthesis of 4-Hydroxy-3(2H)-furanone Acyl Derivatives and Their Anti-cataract Effect on Spontaneous Cataract Rats (ICR/f)

4-Hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF) and 2(or 5)-ethyl-4-hydroxy-5(or 2)-methyl-3(2H)-furanone (EHMF) are known to inhibit cataract development in spontaneous cataract rats (ICR/f). Forty-five acylated hydroxyfuranone derivatives were designed and synthesized for an anti-cataract test, and their hydrophobic constants were also tested. Among these derivatives, 2,5-dimethyl-4-pivaloyloxy-3(2H)-furanone (HDMF pivalate) exerted a marked protective effect against the development of cataract in a galactose-induced model using cultured rat lens (in vitro). When tested on an ICR/f cataract model (in vivo), HDMF pivalate showed more significant inhibition of cataract development than parent compound HDMF. This derivative is more lipophilic than HDMF, so that HDMF pivalate can penetrate the cornea more easily than HDMF. The inhibition of cataract development by HDMF converted from HDMF pivalate is supported by the fact that HDMF was observed in the lens of ICR/f rats treated with HDMF pivalate.