364590-63-6

Basic information

• Product Name: Smoothened Agonist, HCl
• Synonyms: 3-Chloro-N-[4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide;Hh-Ag 1.3;Smoothened Agonist, HCl;SAG . dihydrochloride (water soluble);3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide,hydrate,dihydrochloride
• CAS NO: 364590-63-6
• Molecular Formula: C28H28ClN3OS
• Molecular Weight: 490.05942
• EINECS: -0
• Mol File: 364590-63-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Water Solubility: Soluble in water.
• Sensitive: Light Sensitive & Hygroscopic
• CAS DataBase Reference: Smoothened Agonist, HCl(CAS DataBase Reference)
• NIST Chemistry Reference: Smoothened Agonist, HCl(364590-63-6)
• EPA Substance Registry System: Smoothened Agonist, HCl(364590-63-6)

Safety Data

• Hazardous Substances Data: 364590-63-6(Hazardous Substances Data)

Usage

Description

Smoothened Agonist, HCl (SAG) is a potent activator of the Smo (smoothened) protein, which is a key component of the hedgehog signaling pathway. This chlorobenzothiophene compound interacts with the heptahelical domain of Smo, demonstrating its ability to act as an activator at low concentrations. However, at very high concentrations, SAG can inhibit Smo coupling. The activating effects of SAG are capable of counteracting the inhibition of Smo caused by Cyclopamine or Cyclopamine-KAAD.

Uses

Used in Pharmaceutical Applications:
Smoothened Agonist, HCl is used as a hedgehog pathway agonist for the modulation of various cellular processes and signaling pathways. Its activation of the Smo protein can have significant implications in the development and progression of certain diseases, making it a valuable tool in pharmaceutical research and drug development.
Used in Research and Development:
Smoothened Agonist, HCl is used as a research tool for studying the hedgehog signaling pathway and its role in cellular processes. This application helps researchers understand the underlying mechanisms of various diseases and develop targeted therapies to counteract the effects of aberrant hedgehog signaling.
Used in Drug Delivery Systems:
Smoothened Agonist, HCl can be used as a component in drug delivery systems, particularly for targeted therapies that aim to modulate the hedgehog signaling pathway. By incorporating SAG into these systems, researchers can develop more effective treatments for diseases associated with the hedgehog pathway, such as certain types of cancer.