364630-12-6

Basic information

• Product Name: methyl 9-[2-O-(3,3-di-tert-butyloxycarbonylpropyl)-3-O-benzoyl-4,6-O-benzylidene-β-D-galactopyranosyloxy]-nonanoate
• Synonyms: methyl 9-[2-O-(3,3-di-tert-butyloxycarbonylpropyl)-3-O-benzoyl-4,6-O-benzylidene-β-D-galactopyranosyloxy]-nonanoate
• CAS NO: 364630-12-6
• Molecular Weight: 784.942
• Mol File: 364630-12-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 9-[2-O-(3,3-di-tert-butyloxycarbonylpropyl)-3-O-benzoyl-4,6-O-benzylidene-β-D-galactopyranosyloxy]-nonanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 9-[2-O-(3,3-di-tert-butyloxycarbonylpropyl)-3-O-benzoyl-4,6-O-benzylidene-β-D-galactopyranosyloxy]-nonanoate(364630-12-6)
• EPA Substance Registry System: methyl 9-[2-O-(3,3-di-tert-butyloxycarbonylpropyl)-3-O-benzoyl-4,6-O-benzylidene-β-D-galactopyranosyloxy]-nonanoate(364630-12-6)

Safety Data

• Hazardous Substances Data: 364630-12-6(Hazardous Substances Data)

Upstream product

• 206856-90-8 ethyl 3,4-O-isopropylidene-6-O-tert-butyldimethylsilyl-2-O-(3,3-di-tert-butyloxycarbonylpropyl)-1-thio-β-D-galactopyranoside 
• 206856-93-1 ethyl 2-O-(3,3-di-tert-butyloxycarbonylpropyl)-4,6-O-benzylidene-1-thio-β-D-galactopyranoside 
• 206856-91-9 ethyl 3,4-O-isopropylidene-2-O-(3,3-di-tert-butyloxycarbonylpropyl)-1-thio-β-D-galactopyranoside 
• 206856-92-0 ethyl 2-O-(3,3-di-tert-butyloxycarbonylpropyl)-1-thio-β-D-galactopyranoside 
• 206856-89-5 ethyl 3,4-O-isopropylidene-6-O-tert-butyldimethylsilyl-2-O-methanesulfonyloxyethyl-1-thio-β-D-galactopyranoside 
• 206856-87-3 ethyl 6-O-tert-butyldimethylsilyl-3,4-O-isopropylidene-2-O-tert-butyloxycarbonylmethyl-1-thio-β-D-galactopyranoside 
• 206856-88-4 ethyl 6-O-tert-butyldimethylsilyl-3,4-O-isopropylidene-2-O-hydroxyethyl-1-thio-β-D-galactopyranoside 
• 172146-96-2 ethyl 6-O-tert-butyldimethylsilyl-3,4-O-isopropylidene-1-thio-β-D-galactopyranoside 
• 56245-60-4 ethyl 1-thio-β-D-galactopyranoside 
• 172146-95-1 ethyl 3,4-O-isopropylidene-1-thio-β-D-galactopyranoside 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 34957-73-8 methyl 9-hydroxynonanoate 
• 206856-94-2 ethyl 2-O-(3,3-di-tert-butyloxycarbonylpropyl)-3-O-benzoyl-4,6-O-benzylidene-1-thio-β-D-galactopyranoside 

Relevant articles and documents

Novel mimics of sialyl Lewis X: Design, synthesis and biological activity of a series of 2- and 3-malonate substituted galactoconjugates

A series of potent inhibitors of P-selectin as potential antiinflammatory agents is reported. These compounds are derivatives of galactocerebrosides bearing a malonate side chain in positions 2 and 3 of the galactose moiety. Based on the binding mode of sialyl Lewis X, the two acidic groups of the malonate are designed to form ionic interactions with two important lysines in the active site of P-selectin, Lys113 and Lys111. On the other hand the 4- and 6-hydroxy groups on the galactosering are arranged to chelate the calcium ion in the P-selectin active site. The synthesis and the biological activity of this series of compounds are described. Lead compounds having a greater potency than sialyl lewis X are identified. Copyright