364633-50-1

Basic information

• Product Name: 2-Propenoic acid, 3-(2-chlorophenyl)-2-methyl-, methyl ester, (2E)-
• CAS NO: 364633-50-1
• Molecular Formula: C11H11ClO2
• Molecular Weight: 210.66
• Mol File: 364633-50-1.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-(2-chlorophenyl)-2-methyl-, methyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-(2-chlorophenyl)-2-methyl-, methyl ester, (2E)-(364633-50-1)
• EPA Substance Registry System: 2-Propenoic acid, 3-(2-chlorophenyl)-2-methyl-, methyl ester, (2E)-(364633-50-1)

Safety Data

• Hazardous Substances Data: 364633-50-1(Hazardous Substances Data)

Upstream product

• 154243-34-2 methyl 3-hydroxy-2-methylene-3-(2-chlorophenyl)propanoate 
• 330442-80-3 methyl (2Z)-2-(bromomethyl)-3-(2-chlorophenyl)prop-2-enoate 
• 89-98-5 2-chloro-benzaldehyde 
• 1367876-26-3 [(Z)-3-(2-chlorophenyl)-2-methoxycarbonyl-2-propenyl]triphenylphosphonium bromide 
• 105480-01-1 methyl 3-acetoxy-3-(o-chlorophenyl)-2-methylenepropanoate 
• 108-24-7 acetic anhydride 

Downstream Products

• 1614-98-8 3-(2-chlorophenyl)-2-methylacrylic acid 

Relevant articles and documents

Microwave-assisted synthesis of the (E)-α-methylalkenoate framework from multifunctionalized allylic phosphonium salts

A convenient and general microwave-assisted method for the synthesis of stereochemically defined α-methylalkenoic acids and esters from allylic phosphonium salts in a basic aqueous medium is described. A selective preparation of acids or esters was dependent on the base (NaOH or NaHCO 3) employed in the reaction and could be achieved with good to excellent yields under mild conditions in the absence of hydrides and reducing agents.

Sm/HOAc/EtOH system-mediated reduction of Baylis-Hillman acetates

Selective formation of (2E)-2-methylalk-2-enoates or 2-methyl alkanoates could be achieved in moderate to good yields under mild conditions via Sm/HOAc/EtOH system-mediated reduction of Baylis-Hillman acetates depending on the amount of samarium consumed in the reactions. Copyright Taylor & Francis Group, LLC.

Synthetic applications of Baylis-Hillman chemistry: An efficient and solely stereoselective synthesis of (E)-α-methylcinnamic acids and potent hypolipidemic agent LK-903 from unmodified Baylis-Hillman adducts

An efficient and solely stereoselective synthesis of (E)-α- methylcinnamic acids has been accomplished in single pot by reduction of the unmodified Baylis-Hillman adducts, methyl-3-hydroxy-3-aryl-2- methylenepropanoates with I2/NaBH4 reagent system at room temperature followed by hydrolysis. The efficacy of this method has been proved in the total synthesis of 1-[p-(myristyloxy)-α-methylcinnamoyl]glycerol, LK-903, a highly active hypolipidemic agent.