365-19-5

Basic information

• Product Name: difluoro-acetic acid-(N-methyl-anilide)
• Synonyms: difluoro-acetic acid-(N-methyl-anilide)
• CAS NO: 365-19-5
• Molecular Weight: 185.173
• Mol File: 365-19-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: difluoro-acetic acid-(N-methyl-anilide)(CAS DataBase Reference)
• NIST Chemistry Reference: difluoro-acetic acid-(N-methyl-anilide)(365-19-5)
• EPA Substance Registry System: difluoro-acetic acid-(N-methyl-anilide)(365-19-5)

Safety Data

• Hazardous Substances Data: 365-19-5(Hazardous Substances Data)

Upstream product

• 2588-65-0 N-Methyl-N-<1,2,2-trifluor-vinyl>-anilin 
• 454-31-9 ethyl difluoroacetate 
• 35954-01-9 lithium N-methylanilide 
• 100-61-8 N-methylaniline 
• 62-53-3 aniline 
• 116-14-3 polytetrafluoroethylene 
• 433-53-4 difluoroacetic acid methyl ester 
• 381-72-6 difluoroacetyl chloride 
• 404-17-1 2,2-difluoro-N-phenylacetamide 
• 74-88-4 methyl iodide 

Downstream Products

• 405-17-4 N-(2,2-difluoroethyl)aniline 
• 399-01-9 N-(2,2-Difluoroethyl)-N-methylaniline 

Relevant articles and documents

Electrolytic Reactions of Fluoroorganic Compounds. 14. Regioselective Anodic Methoxylation of N-(Fluoroethyl)amines. Preparation of Highly Useful Fluoroalkylated Building Blocks

Anodic methoxylation of various types of N-(fluoroethyl)amines, ArRNCH2Rf (Rf = CF3, CHF2, CH2F, etc.) has been systematically studied and it was found that a methoxy group was exclusively or preferentially introduced into the position α to the fluoromethyl (Rf) group, depending on the Rf and R groups.The effect of the Rf group on the promotion of the anodic α-methoxylation decreased in the order CF3, CHF2, and CH2F.This remarkable promotion effect and unique regioselectivity can be explained mainly in terms of the α-CH kinetic acidities of the cation radicals formed by one-electron oxidation of the amines.The α-methoxylated products are highly useful precursors for the construction of carbon-carbon bonds α to the trifluoromethyl and difluoromethyl groups, which is difficult by other methods.