3650-09-7 Usage
Description
Carnosic acid, also known as salvin, is a phenolic diterpenoid compound found abundantly in sage and rosemary leaves. It possesses a variety of beneficial properties, including antioxidative, anti-carcinogenic, anti-inflammatory, anti-microbial, anti-adipogenic, antiproliferative, antitumorigenic, and neuroprotective activities. Carnosic acid is a yellow powder and is increasingly being utilized in the food, nutrition, health, and cosmetic industries.
Uses
Used in Food Industry:
Carnosic acid is used as a natural antioxidant for [application type] in the food industry to prevent oxidation and prolong the storage time of various products, such as oils, animal fats, sauces, bakery wares, meat, and fish products. Its antioxidant properties help in stabilizing and increasing the shelf life of these products.
Used in Nutrition and Health Industry:
Carnosic acid is used as a supplement for [application reason] in the nutrition and health industry due to its anti-carcinogenic, anti-inflammatory, and neuroprotective properties. It has been proven to be efficient in the treatment of hyperglycemia, making it a valuable component in health supplements.
Used in Cosmetic Industry:
Carnosic acid is used as an active ingredient for [application type] in the cosmetic industry, particularly in hair care and skin care products. Its anti-adipogenic, anti-inflammatory, and anti-microbial properties make it a valuable addition to these products.
Used in Oral Health Care:
Carnosic acid is used as a protective agent for [application reason] in oral health care products. In vitro studies have shown that it efficiently protects against typical cariogenic microorganisms, making it an important raw material for tooth grinding and gargle agents.
Used in Antioxidant Applications:
Carnosic acid is used as a potent antioxidant for [application type] in various industries, including food, nutrition, health, and cosmetics. Its ability to inhibit the free-radical chain reaction that leads to the oxidation of fats and oils makes it a valuable component in these applications.
Used in UV Protection:
Carnosic acid is used as a UV protectant for [application reason] in the cosmetic industry, specifically for protection against UV-A radiation and damage. Its UV protective activity makes it a valuable ingredient in skin care products.
References
[1] Simona Birtic, Pierre Dussort, Francois-Xavier Pierre, Antoine C. Bily, Marc Roller (2015) Carnosic acid,115, 9-19
[2] https://en.wikipedia.org/wiki/Carnosic_acid
[3] http://www.lvyinbio.com/plant-extract/carnosic-acid/
Anticancer Research
Carnosic acid is a diterpene found in rosemary (Rosmarinus officinalis), exhibitinganti-proliferative effects when observed in vitro in human renal carcinoma cells andcervical carcinoma cells (Su et al. 2016) including inhibition of cell proliferation,angiogenesis and cell migration. ER stress is induced by the carnosic acid present inthe extract from rosemary, inducing cancer cell apoptosis (Cao and Kaufman 2014;Petiwala et al. 2014). Carnosic acid induced dose-dependent expression of ATF4and CHOP and knockdown of CHOP and ATF4 by siRNA-suppressed apoptosis.The role of ROS was investigated in the induction of ER stress by carnosic acid.ATF4 and CHOP expression induced by carnosic acid was markedly inhibited byROS scavengers. Hence, this information implies that ATF4 and CHOP expressionmediated by ER stress plays a significant part in apoptosis of human kidney Cakicells induced by carnosic acid (Min et al. 2014). Treatment of 22Rv1 and LNCaP,human prostate cancer cell lines, by carnosic acid degraded the androgen receptor(AR), and antigen specific to the prostate also showed reduced expression.Proteasomal degradation pathway dependent on ER stress mediates AR degradation.Induction of CHOP protein, degradation of AR and reduction in the growth ofxenograft prostate cancer tumours by 53% were also detected in vivo. Additionally,carnosic acid induces ER stress only in prostate cancer cells and not in normal cells(Petiwala et al. 2016).
Check Digit Verification of cas no
The CAS Registry Mumber 3650-09-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,6,5 and 0 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 3650-09:
(6*3)+(5*6)+(4*5)+(3*0)+(2*0)+(1*9)=77
77 % 10 = 7
So 3650-09-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H28O4/c1-11(2)13-10-12-6-7-14-19(3,4)8-5-9-20(14,18(23)24)15(12)17(22)16(13)21/h10-11,14,21-22H,5-9H2,1-4H3,(H,23,24)/t14?,20-/m1/s1
3650-09-7Relevant articles and documents
Syntheses of carnosic acid and carnosol, anti-oxidants in rosemary, from pisiferic acid, the major constituent of Sawara
Tada, Masahiro,Ohkanda, Tomoyuki,Kurabe, Jun
experimental part, p. 27 - 29 (2010/04/26)
Carnosic acid (2), a major anti-oxidant in rosemary (Rosmarinus officinalis), was synthesized from pisiferic acid (1), the major constituent of Sawara (Chamaecyparis pisifera), via ortho-oxidation of the phenol using metachlorobenzoyl peroxide (mCBPO), chloroacetyl meta-chlorobenzoyl peroxide (CAMCBPO) or 2-iodoxybenzoic acid (IBX). Carnosol (3), another anti-oxidant in rosemary, was synthesized from carnosic acid by oxidation with silver oxide. Potent antibacterial activities against Propionibacterium acnes (ATCC 6919) (minimum inhibitory concentration (MIC) μg/ml) and Staphylococcus aureus ME/GM/TC Resistant (ATCC 33592) (MIC μg/ml) of carnosic acid and carnosol were reported.
