365280-18-8 Usage
Description
(2S,4R)-4-Methylpyrrolidine-2-carboxylic acid hydrochloride is a chiral compound that is an analog of L-Proline, an essential α-amino acid and precursor for collagen synthesis. It plays a crucial role in the formation of various connective tissues, including tendons, ligaments, arteries, veins, and muscles, and is also significant in the wound healing process.
Uses
Used in Pharmaceutical Industry:
(2S,4R)-4-Methylpyrrolidine-2-carboxylic acid hydrochloride is used as a chiral building block for the synthesis of various pharmaceutical compounds. Its unique stereochemistry allows for the development of enantiomerically pure drugs with improved efficacy and reduced side effects.
Used in Nutritional Supplements:
As an analog of L-Proline, (2S,4R)-4-Methylpyrrolidine-2-carboxylic acid hydrochloride is used in nutritional supplements to support collagen production and maintain the health of connective tissues. This can be particularly beneficial for athletes, the elderly, or individuals with compromised collagen synthesis.
Used in Wound Healing Applications:
(2S,4R)-4-Methylpyrrolidine-2-carboxylic acid hydrochloride is used as a wound healing agent due to its role in collagen synthesis and tissue repair. It can be incorporated into topical formulations or bandages to promote faster and more effective healing of cuts, burns, and other injuries.
Used in Research and Development:
In the field of research and development, (2S,4R)-4-Methylpyrrolidine-2-carboxylic acid hydrochloride serves as a valuable tool for studying the mechanisms of collagen synthesis and the role of L-Proline in various biological processes. It can also be used to investigate the effects of chirality on the activity and selectivity of enzymes and other biomolecules.
Check Digit Verification of cas no
The CAS Registry Mumber 365280-18-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,5,2,8 and 0 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 365280-18:
(8*3)+(7*6)+(6*5)+(5*2)+(4*8)+(3*0)+(2*1)+(1*8)=148
148 % 10 = 8
So 365280-18-8 is a valid CAS Registry Number.
365280-18-8Relevant articles and documents
Polyheterocyclic substituted pyrimidines or pyridylamine derivatives Composition and medical application thereof
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Paragraph 0362-0363; 0367, (2021/09/26)
The invention discloses a polycyclic substituted pyrimidine or pyridine amine derivative, and the structure is shown in a formula (I). The invention further discloses a pharmaceutically acceptable salt of the derivative, a solvate, a stereoisomer, a prodrug, a pharmaceutical composition and and an application thereof in medicine. The compounds of the present invention have significant adenosine A. 2A Receptor and/or adenosine A2B The receptor antagonism activity is very practical.
1-[1-(BENZOYL)-PYRROLIDINE-2-CARBONYL]-PYRROLIDINE-2-CARBONITRILE DERIVATIVES
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Page/Page column 28; 32; 33, (2014/05/24)
The present invention relates to 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives having pharmacological activity formula (I) to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of a cognitive disorder.
Concise, stereoselective route to the four diastereoisomers of 4-methylproline
Murphy, Annabel C.,Mitova, Maya I.,Blunt, John W.,Munro, Murray H.G.
experimental part, p. 806 - 809 (2009/04/07)
The full stereochemical characterization of 4-methylproline, a rare amino acid found in a number of peptidic secondary metabolites, has often been hindered by long reaction sequences or low stereoselectivity in the synthesis leading to reference samples. The preparation of the four diastereoisomers of 4-methylproline by a concise and stereoselective route is presented and features a six-step route with late-stage stereodivergence, good stereoselectivity for both cis- and trans-series (75% and 88% de, respectively), and good overall yields (cumulative yields of 30-40%). Additional data on the Marfey's derivatives of the stereoisomers are also presented.
