3655-05-8

Basic information

• Product Name: BOC-GLY-ONP
• Synonyms: BOC-GLY-ONP;BOC-GLYCINE 4-NITROPHENYL ESTER;BOC-GLYCINE P-NITROPHENYL ESTER;BOC-GLYCINE-ONP;4-nitrophenyl N-[(1,1-dimethylethoxy)carbonyl]glycinate;N-T-BOC-GLYCINE P-NITROPHENYL ESTERCRYST ALLINE;N-alpha-t-Butyloxycarbonyl-glycine p-nitrophenyl ester;N-(tert-Butoxycarbonyl)glycine 4-nitrophenyl ester
• CAS NO: 3655-05-8
• Molecular Formula: C₁₃H₁₆N₂O₆
• Molecular Weight: 296.28
• EINECS: 222-900-4
• Product Categories: Amino Acid Derivatives
• Mol File: 3655-05-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 71 °C
• Boiling Point: 457°Cat760mmHg
• Flash Point: 230.2°C
• Appearance: /
• Density: 1.267g/cm³
• Vapor Pressure: 1.54E-08mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: 2-8°C
• PKA: 10.65±0.46(Predicted)
• CAS DataBase Reference: BOC-GLY-ONP(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-GLY-ONP(3655-05-8)
• EPA Substance Registry System: BOC-GLY-ONP(3655-05-8)

Safety Data

• WGK Germany: 3
• F: 8
• Hazardous Substances Data: 3655-05-8(Hazardous Substances Data)

Usage

Chemical Properties

Brown powder

Uses

Substrate for chymotrypsin and trypsin.

InChI:InChI=1/C13H16N2O6/c1-13(2,3)21-12(17)14-8-11(16)20-10-6-4-9(5-7-10)15(18)19/h4-7H,8H2,1-3H3,(H,14,17)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 42538-64-7 Boc-glycine cesium salt 
• 101623-71-6 iodomethyl(4-nitrophenyl)carbonate 
• 50780-50-2 4-chloromethoxycarbonyloxy-1-nitrobenzene 
• 100-02-7 4-nitro-phenol 
• 7647-01-0 hydrogenchloride 
• 4530-20-5 BOC-glycine 
• 107-06-2 1,2-dichloro-ethane 
• 13303-10-1 tert-Butyl 4-nitrophenyl carbonate 
• 6000-44-8 sodium glycinate 
• 18185-77-8 tert-butyloxycarbonylglycine imidazolide 

Downstream Products

• 75410-01-4 t-butoxycarbonylglycyl-L-glutaminylglycine benzyl ester 
• 140647-57-0 N-(t)-butyloxycarbonyl-glycyl-DL-3,3-difluoro-phenylalanyl methyl ester 
• 100-02-7 4-nitro-phenol 
• 14719-37-0 ethyl 2-(tert-butoxycarbonylamino)acetate 
• 1164-16-5 Z-L-Tyr-OH 
• 64645-55-2 N-(benzyloxycarbonyl)-O-<(tert-butoxycarbonyl)glycyl>-L-tyrosine ethyl ester 
• 65853-69-2 N-BOC-glycyl-O-benzyl-L-tyrosin-ethylester 
• 131453-24-2 Boc-Gly-Gln-Cys(MBzl)-Thr-OMe 
• 131453-12-8 Boc-Gly-Cys(MBzl)-Gly-Lys(Z)-OBzl 
• 107326-96-5 Boc-Gly-Trp-Lys(Z)-OCH₃ 
• 4530-20-5 BOC-glycine 
• 35150-09-5 N-(tert-butoxycarbonyl)glycine 
• 17639-39-3 p-nitrophenyl glycinate 
• 717138-75-5 {[3,5-bis-(2-tert-butoxycarbonylamino-acetylamino)-cyclohexylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Kilogram-Scale Synthesis of Osteogenic Growth Peptide (10-14) Using a Fragment Coupling Approach

Kilogram-scale synthesis of a bioactive pentapeptide in solution by "3 + 2" fragment coupling strategy has been successively accomplished in the development of OGP (10-14), a minimal OGP-derived sequence that retains the full proliferative activity of the osteogenic growth peptide. The synthetic scheme, coupling conditions, and scaling-up of the process are systematically studied; the epimerization of the tripeptide fragment and pentapeptide are also evaluated.

Synthesis of a novel cyclic prodrug of S -allyl-glutathione able to attenuate LPS-induced ROS production through the inhibition of MAPK pathways in U937 cells

A novel cyclic prodrug of S-allyl-glutathione (CP11), obtained by using an acyloxy-alkoxy linker, was estimated for its pharmacokinetic and biological properties. The stability of CP11 was evaluated at pH 1.2, 7.4, in simulated fluids with different concentrations of enzymes, and in human plasma. The anti-inflammatory ability of CP11 was assessed in U937 cells, an immortalized human monocyte cell line. Results showed that CP11 is stable at acidic pH showing a possible advantage for oral delivery due to the longer permanence in the stomach. Having a permeability coefficient of 2.49 × 10-6 cm s-1, it was classified as discrete BBB-permeable compound. Biological studies revealed that CP11 is able to modulate inflammation mediated by LPS in U937 cells preventing the increase of ROS intracellular levels through interaction with the MAPK pathway.

PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO

This document discloses molecules having the following formula ("Formula One"): and processes associated therewith.