3659-77-6

Basic information

• Product Name: 4-METHYL-2-PHENYLBENZIMIDAZOLE
• Synonyms: 4-METHYL-2-PHENYLBENZIMIDAZOLE
• CAS NO: 3659-77-6
• Molecular Formula: C₁₄H₁₂N₂
• Molecular Weight: 208.263
• Mol File: 3659-77-6.mol
• Article Data: 37

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-METHYL-2-PHENYLBENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-2-PHENYLBENZIMIDAZOLE(3659-77-6)
• EPA Substance Registry System: 4-METHYL-2-PHENYLBENZIMIDAZOLE(3659-77-6)

Safety Data

• Hazardous Substances Data: 3659-77-6(Hazardous Substances Data)

Upstream product

• 73902-63-3 N-(2-methyl-6-nitrophenyl)benzamide 
• 36954-10-6 N-o-tolyl-benzamide oxime 
• 98-09-9 benzenesulfonyl chloride 
• 611-73-4 Benzoylformic acid 
• 2687-25-4 3-methyl-1,2-benzenediamine 
• 100-51-6 benzyl alcohol 
• 57327-73-8 N-(o-tolyl)benzimidamide 
• 698-16-8 benzohydroximoyl chloride 
• 100-52-7 benzaldehyde 
• 570-24-1 2-Methyl-6-nitroaniline 
• 100-39-0 benzyl bromide 
• 342894-88-6 C₁₄H₁₆N₂ 
• 100-46-9 benzylamine 
• 591-50-4 iodobenzene 

Downstream Products

• 1370000-19-3 C₁₉H₂₁N₃ 
• 1370000-27-3 C₁₄H₁₀N₂O 
• 1417819-40-9 11-methyl-6-phenylbenzo[4,5]imidazo[2,1-a]isoquinoline 

Relevant articles and documents

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Preparation method of 2-substituted benzimidazole compound

The invention discloses a preparation method of a 2-substituted benzimidazole compound, and belongs to the field of synthesis of benzimidazole compounds. The 2-substituted benzimidazole compound is synthesized in an organic solvent by taking an o-nitroaniline compound, aromatic aldehyde, o-dinitrobenzene and aromatic aldehyde as raw materials and taking Co particles wrapped by a nitrogen-doped carbon material as a catalyst. According to the method, the 2-substituted benzimidazole compound can be prepared at room temperature, the reaction conditions are mild, the yield is as high as 95%, the selectivity is as high as 99%, and the method is economical, environmentally friendly and wide in substrate applicability. The used catalyst is easy to prepare, low in cost and good in reusability, canbe separated by utilizing magnetism, and is convenient to recover, so that the method has a relatively strong industrial application prospect.

New synthesis method of thiabendazole

The invention relates to a new synthetic route of a drug commonly named as thiabendazole. Thiazole-4-formaldehyde is used as a raw material, and is condensed with hydroxylamine hydrochloride to obtainthiazole-4-formaldoxime, thiazole-4-formaldoxime is subjected to chlorination by using NCS, and then reacts with aniline to obtain N-phenylthiazole-4-methylamine oxime, then N-phenylthiazole-4-methylamine oxime reacts with p-trifluoromethyl benzoyl chloride to obtain an amidoxime ester, and finally a visible-light-catalyzed free radical reaction is adopted for cyclization to obtain thiazole. According to the method, the visible-light-catalyzed free radical reaction is used to the synthesis of thiabendazole for the first time, the reaction conditions of a high temperature and a strong acid inthe traditional synthesis method are avoided, and thereby the reaction is greener and milder. The method has a broad spectrum, and can also be used for synthesis of imidazole compounds Ia-Ial.