365996-05-0

Basic information

• Product Name: TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE
• Synonyms: 5-Boc-2-Amino-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine;4,5,6,7-tetrahydro-5-Boc-thiazolo[5,4-c]pyridin-2-amine;2-Amino-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester;4-c]pyridine-5(4H)-carboxylate;7-dihydrothiazolo[5;tert-butyl 2-aMino-6;tert-butyl 2-aMino-6.7-dihydrothiazolo[5.4-c]pyridine-5(4H)-carb;2-AMino-5-Boc-6,7-dihydro-4H-thiazolo-[5,4,c]pyridine
• CAS NO: 365996-05-0
• Molecular Formula: C₁₁H₁₇N₃O₂S
• Molecular Weight: 255.34
• Product Categories: CHIRAL CHEMICALS;Heterocycle-Pyridine series
• Mol File: 365996-05-0.mol
• Article Data: 33

Chemical Properties

• Melting Point: 91-94 °C
• Boiling Point: 412.789 °C at 760 mmHg
• Flash Point: 203.448 °C
• Appearance: Off-white to brown/Crystalline Powder
• Density: 1.28 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 5.23±0.20(Predicted)
• CAS DataBase Reference: TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE(365996-05-0)
• EPA Substance Registry System: TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE(365996-05-0)

Safety Data

• Hazardous Substances Data: 365996-05-0(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE is a chemical compound with the molecular formula C13H18N3O2S. It is a pyridine derivative that contains an amino group and a carboxylate functional group. TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE is commonly used in the pharmaceutical and agrochemical industries for its potential as a drug candidate or pesticide. Its specific properties and potential uses may vary depending on the specific application and formulation in which it is used.

InChI:InChI=1/C11H17N3O2S/c1-11(2,3)16-10(15)14-5-4-7-8(6-14)17-9(12)13-7/h4-6H2,1-3H3,(H2,12,13)

Upstream product

• 420-04-2 CYANAMID 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 207691-65-4 N-tert-butoxycarbonyl-4-(tetrahydropyrrole-1-yl)-1,2,3,6-tetrahydropyridine 
• 17356-08-0 thiourea 
• 188869-05-8 tert-butyl 3-bromo-4-oxo-piperidine-1-carboxylate 
• 60-35-5 acetamide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 97817-23-7 2-Amino-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine 
• 41661-47-6 piperidin-4-one 
• 118652-88-3 3-bromo-piperidin-4-one-hydrobromide 
• 123-75-1 pyrrolidine 

Downstream Products

• 1440954-95-9 2-phenoxycarbonylamino-6,7-dihydro-4H-thiazolo(5,4-c)pyridine-5-carboxylic acid tert-butyl ester 
• 1221918-39-3 C₂₃H₂₃N₃O₃S 
• 1221931-47-0 C₂₇H₃₁N₃O₃S 
• 1221931-45-8 C₁₅H₁₅N₂O₂S^(1-)*Na⁽¹⁺⁾ 
• 1016886-95-5 C₁₅H₁₅N₃S 
• 1221931-40-3 2-chloro-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylic acid tert-butyl ester 
• 1057650-25-5 tert-butyl 2-(2-{[(5-chlorothiophen-2-yl)carbonylamino]methyl}benzoylamino)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylate 
• 365996-06-1 2-Bromo-5-tert-butoxycarbonyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine 
• 143150-92-9 2-Bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]-pyridine 

Relevant articles and documents

Novel 5,6,7,8-tetrahydroimidazo[2′,1′:2,3]thiazolo[5,4-c]pyridine derivatives

Starting with 4-piperidone, new 5,6,7,8-tetrahydroimidazo[2′,1′:2,3]thiazolo [5,4-c]pyridines were synthesized. Structures of these compounds were confirmed by 1H NMR, 13C NMR, MS and elemental analysis.

Identification of novel GPR81 agonist lead series for target biology evaluation

GPR81 is a novel drug target that is implicated in the control of glucose and lipid metabolism. The lack of potent GPR81 modulators suitable for in vivo studies has limited the pharmacological characterization of this lactate sensing receptor. We performed a high throughput screen (HTS) and identified a GPR81 agonist chemical series containing a central acyl urea scaffold linker. During SAR exploration two additional new series were evolved, one containing cyclic acyl urea bioisosteres and another a central amide bond. These three series provide different selectivity and physicochemical properties suitable for in-vivo studies.

Preparation 2 - amino - 5 - CBZ - 4, 5, 6, 7 - tetrahydro-thiazolo [5, 4 - C] pyridine of the new method (by machine translation)

The invention discloses a process for preparing 2 - amino - 5 - CBZ - 4, 5, 6, 7 - tetrahydro-thiazolo [5, 4 - C] pyridine of the new method, comprises the following steps: N - tert-butoxycarbonyl - 4 - piperidone in pyridine with sulfur and single cyanamide mixed heating reaction→cooling→filtering→washed with an organic solvent, and dried to obtain a pale yellow solid product→in dichloromethane in trifluoroacetic acid is mixed with low-temperature reaction, concentrated→with triethylamine in dichloromethane in the mixed low-temperature drop chlorination benzyl formate, stirring reaction→[...]→dichloromethane extraction, the organic phase water, salt water washing, drying, filtering and concentrated to obtain crude product→ethyl acetate beating, the final product is obtained yellow solid. The invention of cheap price for raw materials to replace the original high price of the raw material for preparing the final product, to avoid the original ring-brominated by-product when many routes, not only the operation is simple, convenient purification, the cost is reduced, high yield, favorable to the industrialized production and cost control. (by machine translation)