366453-21-6

Basic information

• Product Name: 1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI)
• Synonyms: 1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI);4-hydroxyisoindolin-1-one;1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy-;4-Hydroxy-2,3-dihydroisoindol-1-one;2,3-Dihydro-4-hydroxy-1H-isoindol-1-one, 2,3-Dihydro-4-hydroxy-1-oxo-1H-isoindole;2,3-Dihydro-4-hydroxy-1H-isoindol-1-one
• CAS NO: 366453-21-6
• Molecular Formula: C8H7NO2
• Molecular Weight: 149.14668
• Product Categories: ALCOHOL
• Mol File: 366453-21-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 476.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.362±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.01±0.20(Predicted)
• CAS DataBase Reference: 1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI)(366453-21-6)
• EPA Substance Registry System: 1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI)(366453-21-6)

Safety Data

• Hazardous Substances Data: 366453-21-6(Hazardous Substances Data)

Usage

General Description

The chemical 1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy- (9CI) is a compound with the molecular formula C8H7NO2. It is a derivative of isoindole and is classified as a dihydroxyphenylalanine derivative. This chemical is a white solid with a melting point of 167-168°C. It is mainly used in research and experimental studies, with potential applications in pharmaceuticals and organic synthesis. The compound's properties and potential applications make it a subject of interest for further research and development.

Upstream product

• 90-02-8 salicylaldehyde 
• 1290140-08-7 O-ethyl [tert-butyl-[[2-[(4-methoxyphenyl)methoxy]phenyl]methyl]carbamoyl]sulfanylmethanethioate 
• 1290140-09-8 2-tert-butyl-4-[(4-methoxyphenyl)methoxy]-3H-isoindol-1-one 
• 1290140-07-6 N-[[2-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2-methylpropane-2-amine 
• 209120-28-5 2-[(4-methoxyphenyl)methoxy]benzaldehyde 
• 55289-06-0 3-methoxy-2-methylbenzoic acid 
• 71887-28-0 methyl 2-(bromomethyl)-3-methoxybenzoate 
• 42981-93-1 3-methoxy-2-methylbenzoic acid methyl ester 
• 366453-22-7 4-methoxyisoindolin-1-one 

Relevant articles and documents

Synthesis and antibacterial activity of pleuromutilin derivatives with novel C(14) side chain

In order to find novel antibacterial agents with superior antibacterial activity and overcoming multidrug resistance, a series of pleuromutilin derivatives with novel C(14) side chain were synthesized and evaluated for their in vitro antibacterial activit

Convenient access to isoindolinones via carbamoyl radical cyclization. Synthesis of cichorine and 4-hydroxyisoindolin-1-one natural products

An efficient and convenient access to 2-tert-butylisoindolin-1-ones via an oxidative radical cyclization process from stable carbamoylxanthates, derived from secondary tert-butylamines, is described. The proposed mechanism for this transformation involves, the generation of a carbamoyl radical, its cyclization to the aromatic system, and the dilauroyl peroxide (DLP) mediated rearomatization to generate the isoindolinone ring system. Additionally, the syntheses of cichorine and 4-hydroxyisoindolin-1-one natural products were carried out to underscore the synthetic potential of this xanthate-based carbamoyl radical-oxidative cyclization.

Non-nucleoside reverse transcriptase inhibitors

Compounds represented by formula I: wherein R1 is H, halogen, (C1-4)alkyl, O(C1-4)alkyl, and haloalkyl; R2 is H or (C1-4)alkyl; R3 is H or (C1-4)alkyl; R4 is (C1-4)alkyl, (C1-4)alkyl(C3-7)cycloalkyl, or (C3-7)cycloalkyl; and Q is a fused phenyl-5 or 6-membered saturated heterocycle having one to two heteroatoms selected from O and N, said Q being optionally substituted with hydroxy, or (C1-4)alkyl which in turn maybe optionally substituted with pyridinyl-N-oxide or C(O)OR wherein R is H or (C1-4)alkyl; or a salt thereof. The compounds have inhibitory activity against Wild Type, and single and double mutants strains, of HIV.