36685-67-3

Basic information

• Product Name: (E)-1-(2-hydroxy-4-methoxyphenyl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one
• CAS NO: 36685-67-3
• Molecular Weight: 314.338
• Mol File: 36685-67-3.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: (E)-1-(2-hydroxy-4-methoxyphenyl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(2-hydroxy-4-methoxyphenyl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one(36685-67-3)
• EPA Substance Registry System: (E)-1-(2-hydroxy-4-methoxyphenyl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one(36685-67-3)

Safety Data

• Hazardous Substances Data: 36685-67-3(Hazardous Substances Data)

Usage

Description

(E)-1-(2-hydroxy-4-methoxyphenyl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one, commonly known as Curcumenol, is a naturally occurring compound derived from the plant Curcuma longa, or turmeric. It belongs to the class of compounds known as curcumenoids and is a derivative of curcumin. Curcumenol has been the subject of medical research due to its potential anti-inflammatory, antioxidant, and anticancer properties. It is recognized for its ability to inhibit tumor growth, induce apoptosis in cancer cells, and has shown potential cardioprotective and neuroprotective effects. Further investigation is necessary to fully comprehend its mechanisms of action and explore its possible therapeutic applications.

Uses

Used in Pharmaceutical Industry:
Curcumenol is used as a potential therapeutic agent for its anti-inflammatory, antioxidant, and anticancer properties. It is being studied for its ability to inhibit tumor growth and induce apoptosis in cancer cells, which could lead to the development of novel treatments for various types of cancer.
Used in Nutraceutical Industry:
In the nutraceutical industry, Curcumenol is utilized for its potential health benefits, which include its antioxidant and anti-inflammatory properties. These properties may contribute to the development of dietary supplements and functional foods that promote overall health and well-being.
Used in Cosmetic Industry:
Curcumenol's potential anti-inflammatory and antioxidant properties also make it a candidate for use in the cosmetic industry. It could be incorporated into skincare products aimed at reducing inflammation, promoting skin health, and providing protection against oxidative stress.
Used in Research and Development:
Curcumenol is used as a subject of research in the field of medical and pharmaceutical sciences. Its potential cardioprotective and neuroprotective effects are of particular interest, and further research could lead to the development of new treatments for heart and neurological conditions.

Upstream product

• 67756-04-1 1-(2,4-dimethoxy-phenyl)-prop-2-en-1-one 
• 20469-63-0 1-iodo-2,4-dimethoxybenzene 
• 79004-62-9 RL334 
• 75629-23-1 2-(2,4-Dimethoxy-phenyl)-8-[5-(2,4-dimethoxy-phenyl)-6-(2-hydroxy-4-methoxy-benzoyl)-3-methyl-cyclohex-2-enyl]-5-hydroxy-7-methoxy-3-(3-methyl-but-2-enyl)-chromen-4-one 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 108-46-3 recorcinol 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 

Downstream Products

• 132351-64-5 7,2',4'-trimethoxyflavanone 
• 7678-84-4 3-(2,4-dimethoxyphenyl)-7-methoxy-4H-chromen-4-one 
• 7578-51-0 2-(2,4-dimethoxyphenyl)-7-methoxy-4H-chromen-4-one 
• 79056-24-9 8-[(1S,5R,6S)-6-(2,4dDihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3-methyl-2-buten-1-yl)-4H-chromen-4-one 
• 1218939-24-2 (E)-3-(2,4-dimethoxyphenyl)-1-(4-methoxy-2-[(3-methylbut-2-en-1-yl)oxy]phenyl)prop-2-en-1-one 
• 1392231-78-5 (E)-3-(2,4-dimethoxyphenyl)-1-(2-hydroxy-4-methoxy-5-(3-methylbut-2-enyl)phenyl)prop-2-en-1-one 
• 76863-33-7 (E)-3-(2,4-dimethoxyphenyl)-1-[2-hydroxy-4-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]prop-2-en-1-one 
• 1346458-01-2 1-(4-aminosulfonylphenyl)-3-(2-hydroxy-4-methoxyphenyl)-5-(2,4-dimethoxyphenyl)pyrazoline 

Relevant articles and documents

Total Synthesis of Mulberry Diels-Alder-Type Adducts Kuwanons G and H

Mulberry Diels-Alder-type adducts (MDAAs) are a group of rare natural polyphenols biosynthetically derived from [4 + 2]-cycloaddition of chalcones and dehydroprenylphenols. In this study, kuwanons G (1) and H (2), two bioactive MDAAs with unique dehydroprenylflavonoid dienes, were totally synthesized for the first time in a biomimetic manner. The key features of the convergent route include the use of the Baker-Venkataraman rearrangement, alkylation of β-diketone, intramolecular cyclization, and Suzuki-Miyaura coupling to achieve the subunit diene.

Total synthesis of (±)-kuwanol e

The total synthesis of the Diels-Alder-type adducts (±)-kuwanol E and the heptamethyl ether derivative of (±)-kuwanon Y has been accomplished via a convergent strategy involving 2′-hydroxychalcone 6 or 9 and dehydroprenylstilbene 7, in nine steps. The syn

Synthesis of 1-(4-aminosulfonylphenyl)-3,5-diarylpyrazoline derivatives as potent antiinflammatory and antimicrobial agents

A new series of 1-(4-aminosulfonylphenyl)-3, 5-diaryl pyrazolines (5) was synthesized by the reaction of appropriate chalcones 3 with 4- hydrazinobenzenesulfonamide hydrochloride (4) in ethanol in the presence of catalytic amount of acetic acid. All newly