36691-02-8

Basic information

• Product Name: ethyl 2-(4-(1-oxoisoindolin-2-yl)phenyl)butanoate
• Synonyms: ethyl 2-(4-(1-oxoisoindolin-2-yl)phenyl)butanoate
• CAS NO: 36691-02-8
• Molecular Weight: 323.392
• Mol File: 36691-02-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl 2-(4-(1-oxoisoindolin-2-yl)phenyl)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-(1-oxoisoindolin-2-yl)phenyl)butanoate(36691-02-8)
• EPA Substance Registry System: ethyl 2-(4-(1-oxoisoindolin-2-yl)phenyl)butanoate(36691-02-8)

Safety Data

• Hazardous Substances Data: 36691-02-8(Hazardous Substances Data)

Upstream product

• 74-96-4 ethyl bromide 
• 36691-01-7 ethyl 2-(4-(1-oxoisoindolin-2-yl)phenyl)acetate 
• 57960-76-6 ethyl 2-(4-(benzylamino)phenyl)acetate 
• 5438-70-0 ethyl (4-amino-3,5-dibromophenyl)acetate 
• 100-39-0 benzyl bromide 
• 943742-86-7 C₁₂H₁₅BrO₂ 
• 496-12-8 isoindoline 

Downstream Products

• 63610-08-2 indobufen 

Relevant articles and documents

α-Angelica Lactone in a New Role: Facile Access to N-Aryl Tetrahydroisoquinolinones and Isoindolinones via Organocatalytic α-CH2 Oxygenation

A method for the direct oxidation of various N-aryl tetrahydroisoquinolines and isoindolines to the corresponding lactams using α-angelica lactone as a catalyst was developed. The utility of the method was further demonstrated by synthesis of indoprofen and indobufen.

method for preparing indobufen using micro flow reactor

The present invention relates to a method for producing indobufen using ethyl 2-(4-aminophenyl)acetate, which can be industrially purchased, as a starting material and a method for applying the same to a micro flow reactor. According to the present invention, by producing indobufen using a micro flow reactor, the yield and purity of the produced indobufen can be improved, and time spent for the overall production procedure can be reduced. Accordingly, harmful compounds used during the production procedure can be stably used.