367-51-1 Usage
Description
Sodium thioglycolate, also known as the sodium salt of thioglycolic acid, is a white powder with a slight odor. It is a versatile compound with various applications across different industries due to its unique chemical properties.
Uses
Used in Hair Industry:
Sodium thioglycolate is used as a depilatory agent for hair removal and as a key component in cold-waving of hair. It works by breaking the disulfide bonds in hair proteins, allowing the hair to be easily removed or styled.
Used in Bacteriology:
In bacteriology, sodium thioglycolate is used as a chelating agent for the preparation of thioglycolate media. This media is essential for the growth and maintenance of certain bacteria, making it a crucial component in bacterial research and analysis.
Used in Analytical Chemistry:
Sodium thioglycolate serves as an analytical reagent, particularly in the study of thioglycolic acid. Its chelating properties make it a valuable tool for various analytical processes.
Used in Enrichment Media:
As a growth supplement in enrichment media, sodium thioglycolate is used to study its effect on Arcobacter, a genus of bacteria. It helps in reducing disulfide-mediated cross-linking and early potency loss, which is particularly important in electron microscopy.
Used in Inflammation Hemagglutinin Formulation:
Sodium thioglycolate has been utilized in the formulation of influenza hemagglutinin to reduce disulfide-mediated cross-linking, which can lead to early potency loss. This application is significant in the development of vaccines and other medical treatments.
Air & Water Reactions
Hygroscopic. Discolors on exposure to air. Water soluble.
Reactivity Profile
Sodium thioglycolate is hygroscopic and sensitive to air. Discolors if exposed to iron . May generate flammable and toxic hydrogen sulfide with strong reducing agents.
Hazard
Yields toxic hydrogen sulfide on decompo-
sition, may be toxic by skin absorption.
Fire Hazard
Flash point data for Sodium thioglycolate are not available. Sodium thioglycolate is probably combustible.
Flammability and Explosibility
Nonflammable
Biochem/physiol Actions
Sodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo.
Safety Profile
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. A human skin irritant. This material yields hydrogen sulfide on decomposition. A death has been attributed to the absorption of toxic decomposition products from the use of this material in a hair permanent-waving solution. When heated to decomposition it emits toxic fumes of SOx and Na2O. See also SULFIDES and MERCAPTANS.
Purification Methods
It crystallises from 60% EtOH (charcoal). It is hygroscopic.[Beilstein 3 IV 600.]
Check Digit Verification of cas no
The CAS Registry Mumber 367-51-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,6 and 7 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 367-51:
(5*3)+(4*6)+(3*7)+(2*5)+(1*1)=71
71 % 10 = 1
So 367-51-1 is a valid CAS Registry Number.
InChI:InChI=1/C2H4O2S.Na/c3-2(4)1-5;/h5H,1H2,(H,3,4);/q;+1/p-1
367-51-1Relevant articles and documents
High-value utilization method of sodium 2-mercaptoacetate in thionocarbamate production tail liquid
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Paragraph 0079-0080, (2021/08/11)
The invention belongs to wastewater treatment, and particularly discloses a high-value utilization method of sodium 2-mercaptoacetate in thionocarbamate production tail liquid. According to the method, sodium 2-mercaptoacetate in the thionocarbamate production tail liquid is used as a raw material and reacts with thiocyanate and a halogenating reagent to obtain the S-carboxyethyl-N-alkanoyl dithiocarbamate. The method is simple to operate and high in efficiency, solves the problem that the sodium 2-mercaptoacetate in the thionocarbamate production tail liquid is difficult to recover, and can realize high-value utilization of the sodium 2-mercaptoacetate.
Method for utilizing byproduct 2-sodium thioglycollate in production process of thionocarbamate
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Paragraph 0038, (2019/12/25)
The invention belongs to wastewater treatment and in particular discloses a method for utilizing a byproduct 2-sodium thioglycollate in the production process of thionocarbamate. The method comprisesthe following steps: by taking a byproduct 2-sodium thioglycollate in the production process of thionocarbamate as a raw material, enabling the byproduct to react with a halogenation reagent so as toobtain alkyl thioether acetic acid; performing esterification on the alkyl thioether acetic acid with methanol so as to obtain alkyl thioether methyl acetate; and further enabling the alkyl thioethermethyl acetate to react with hydroxylamine hydrochloride, so as to obtain alkyl thioether ethyl hydroximic acid. By adopting the method, the problem that the byproduct 2-sodium thioglycollate in a process of thionocarbamate is hard to recycle can be solved, the utilization rate of the byproduct is increased, and the environment can be protected.
COMPOSITION AND METHODS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME AND ACUTE MYELOID LEUKEMIA
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, (2010/12/29)
Methods and compositions are provided for treating myelodysplastic syndrome and acute myeloid leukemia, wherein the composition comprises at least one compound according to Formula I: wherein R1 is selected from the group consisting of —NH2, —NH—CH2—CO2H, —NH—CH(CH3)—CO2H, and —NH—C(CH3)2—CO2H, or a pharmaceutically acceptable salt of such a compound; and a DNA methyltransferase inhibitor, or a pharmaceutically acceptable salt thereof.
