36707-43-4

Basic information

• Product Name: diethyl ({[6-(acetylamino)-2-(methylsulfanyl)pyrimidin-4-yl]amino}methylidene)propanedioate
• CAS NO: 36707-43-4
• Molecular Formula: C₁₅H₂₀N₄O₅S
• Molecular Weight: 368.4081
• Mol File: 36707-43-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 539.2°C at 760 mmHg
• Flash Point: 279.9°C
• Density: 1.31g/cm³
• Vapor Pressure: 1.07E-11mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: diethyl ({[6-(acetylamino)-2-(methylsulfanyl)pyrimidin-4-yl]amino}methylidene)propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl ({[6-(acetylamino)-2-(methylsulfanyl)pyrimidin-4-yl]amino}methylidene)propanedioate(36707-43-4)
• EPA Substance Registry System: diethyl ({[6-(acetylamino)-2-(methylsulfanyl)pyrimidin-4-yl]amino}methylidene)propanedioate(36707-43-4)

Safety Data

• Hazardous Substances Data: 36707-43-4(Hazardous Substances Data)

Upstream product

• 41343-58-2 diethyl 2-ethoxymaleate 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 1005-39-6 4,6-diamino-2-methylthiopyrimidine 
• 108-24-7 acetic anhydride 
• 36707-42-3 diethyl 2-((6-amino-2-(methylthio)pyrimidin-4-ylamino)methylene)malonate 

Downstream Products

• 36707-00-3 4-amino-5,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide 
• 36707-44-5 4-acetylamino-2-methylsulfanyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester 

Relevant articles and documents

COMPOUNDS USEFUL AS AKT/PKB MODULATORS AND USES THEREOF

Compounds, and pharmaceutical compositions, and formulations thereof, are disclosed that have formula (I): where R1a, R1b, R1c, R2, R3, R6a, R6b, R6c, R7, and R8 are as defined herein. The compounds, pharmaceutical compositions, and pharmaceutical formulations thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others. The manufacturing and analytical methods for LD- 101 are also disclosed.

Antibacterial compounds

Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.