36779-17-6

Basic information

• Product Name: methyl 2-phenyl-1H-indole-3-carboxylate
• CAS NO: 36779-17-6
• Molecular Formula: C₁₆H₁₃NO₂
• Molecular Weight: 251.2799
• Mol File: 36779-17-6.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 468°C at 760 mmHg
• Flash Point: 236.8°C
• Density: 1.225g/cm³
• Vapor Pressure: 6.21E-09mmHg at 25°C
• Refractive Index: 1.651
• CAS DataBase Reference: methyl 2-phenyl-1H-indole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-phenyl-1H-indole-3-carboxylate(36779-17-6)
• EPA Substance Registry System: methyl 2-phenyl-1H-indole-3-carboxylate(36779-17-6)

Safety Data

• Hazardous Substances Data: 36779-17-6(Hazardous Substances Data)

Usage

General Description

Methyl 2-phenyl-1H-indole-3-carboxylate is a chemical compound with the molecular formula C17H15NO2. It is a methyl ester derivative of 2-phenyl-1H-indole-3-carboxylic acid and belongs to the class of organic compounds known as indolecarboxylic acids and derivatives. methyl 2-phenyl-1H-indole-3-carboxylate is used in the synthesis of pharmaceuticals and in the production of perfumes and fragrances. Its structure consists of a phenyl group, a carboxylic acid ester group, and an indole ring, which gives it its characteristic odor and chemical properties. Methyl 2-phenyl-1H-indole-3-carboxylate has applications in various industries and is a valuable building block for the creation of diverse chemical compounds.

Upstream product

• 65417-26-7 methyl 4-methyl-2-phenyl-3,1-benzoxazepine-5-carboxylate 
• 65417-25-6 methyl 2-phenyl-3,1-benzoxazepine-5-carboxylate 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 13141-38-3 2-phenylethynylaniline 
• 65417-19-8 methyl 2-phenylquinoline-4-carboxylate 1-oxide 
• 107-18-6 allyl alcohol 
• 75-65-0 tert-butyl alcohol 
• 74960-55-7 methyl 1-acetyl-2-phenylindole-3-carboxylate 
• 88344-50-7 dimethyl 2-phenylquinoline-3,4-dicarboxylate 1-oxide 
• 610315-35-0 1-methoxy-2-phenyl-1H-indole-3-carboxylic acid methyl ester 
• 26465-37-2 dimethyl 2-(2-nitrophenyl)malonate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 610315-34-9 dimethyl 2-benzyl-2-(2-nitrophenyl)malonate 

Downstream Products

• 1278540-60-5 C₃₀H₂₂ClNO₃ 
• 1278540-65-0 C₂₃H₁₉NO₂ 
• 1278540-55-8 C₂₃H₁₆ClNO₃ 
• 4662-03-7 2-phenylindole-3-acetic acid 
• 27005-52-3 2-(2-phenyl-1H-indol-3-yl)acetonitrile 
• 773875-08-4 methyl 1-methyl-2-phenyl-1H-indole-3-carboxylate 
• 1380395-20-9 methyl 1-benzyl-2-phenyl-1H-indole-3-carboxylate 
• 18735-98-3 5,11-dihydro-indolo[3,2-c]quinolin-6-one 
• 59050-41-8 2-phenyl-1-methylindole-3-carboxylic acid 
• 74960-55-7 methyl 1-acetyl-2-phenylindole-3-carboxylate 

Relevant articles and documents

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Copper(ii)-catalyzed synthesis of multisubstituted indoles through sequential Chan-Lam and cross-dehydrogenative coupling reactions

Starting from arylboronic acids and ester (Z)-3-aminoacrylates, one-pot syntheses of diverse indole-3-carboxylic esters have been described through copper(ii)-catalyzed sequential Chan-Lam N-arylation and cross-dehydrogenative coupling (CDC) reactions. The initial Chan-Lam arylation can proceed in DMF at 100 °C for 24 h to give ester (Z)-3-(arylamino)acrylate intermediates in the presence of Cu(OAc)2/tri-tert-butylphosphine tetrafluoroborate, a catalytic amount of myristic acid as the additive, KMnO4 and KHCO3. Sequentially, these in situ arylated intermediates can undergo an intramolecular oxidative cross-dehydrogenative coupling process in mixed solvents (DMF/DMSO = 2 : 1) at 130 °C to give C3-functionalized multi-substituted indole derivatives. This journal is

Metal-Free Tandem Rearrangement/Lactonization: Access to 3,3-Disubstituted Benzofuran-2-(3H)-ones

A novel metal-free synthesis of 3,3-disubstituted benzofuran-2-(3H)-ones through reacting α-aryl-α-diazoacetates with triarylboranes is presented. Initially, triarylboranes were successfully investigated in α-arylations of α-diazoacetates, however in the presence of a heteroatom in the ortho position, the boron enolate intermediate undergoes an intramolecular rearrangement to form a quaternary center. The intermediate cyclizes to afford valuable 3,3-disubstituted benzofuranones in good yields.

Copper-Catalyzed Synthesis of Multisubstituted Indoles through Tandem Ullmann-Type C-N Formation and Cross-dehydrogenative Coupling Reactions

Multisubstituted indoles were synthesized via a one-pot tandem copper-catalyzed Ullmann-type C-N bond formation/intramolecular cross-dehydrogenative coupling process at 130 °C in DMSO. The methodology allows practical and modular assembly of indoles in go