367968-06-7

Basic information

• Product Name: (S)-Methyl 2-Bi-((Tert-Butoxycarbonyl)Amino)-5-Hydroxypentanoate
• Synonyms: (S)-Methyl 2-Bi-((Tert-Butoxycarbonyl)Amino)-5-Hydroxypentanoate;(S)-Methyl 2-Bi-((Tert-Butoxycarbonyl)Amino)-5-Hydroxypentanoate(WXC03587)
• CAS NO: 367968-06-7
• Molecular Formula: C16H29NO7
• Molecular Weight: 347.40396
• Mol File: 367968-06-7.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-Methyl 2-Bi-((Tert-Butoxycarbonyl)Amino)-5-Hydroxypentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-Methyl 2-Bi-((Tert-Butoxycarbonyl)Amino)-5-Hydroxypentanoate(367968-06-7)
• EPA Substance Registry System: (S)-Methyl 2-Bi-((Tert-Butoxycarbonyl)Amino)-5-Hydroxypentanoate(367968-06-7)

Safety Data

• Hazardous Substances Data: 367968-06-7(Hazardous Substances Data)

Usage

Description

(S)-Methyl 2-Bi-((Tert-Butoxycarbonyl)Amino)-5-Hydroxypentanoate is a chemical compound with the molecular formula C15H27NO6, derived from the amino acid valine. It is an ester belonging to the class of organic compounds and is characterized by its specific chemical properties. (S)-Methyl 2-Bi-((Tert-Butoxycarbonyl)Amino)-5-Hydroxypentanoate is commonly utilized in the synthesis of peptides and other bioactive molecules, making it a valuable asset in the fields of organic chemistry and pharmaceutical research. Its potential pharmaceutical applications, particularly in the development of new drugs, have also been a subject of study.

Uses

Used in Pharmaceutical Research:
(S)-Methyl 2-Bi-((Tert-Butoxycarbonyl)Amino)-5-Hydroxypentanoate is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of complex organic molecules, which can be further developed into potential drugs.
Used in Peptide Synthesis:
In the field of peptide synthesis, (S)-Methyl 2-Bi-((Tert-Butoxycarbonyl)Amino)-5-Hydroxypentanoate serves as a crucial building block. Its incorporation into peptide structures can lead to the development of bioactive molecules with specific therapeutic properties.
Used in Organic Chemistry:
(S)-Methyl 2-Bi-((Tert-Butoxycarbonyl)Amino)-5-Hydroxypentanoate is also used as a versatile compound in organic chemistry. Its reactivity and structural features make it suitable for various chemical reactions, contributing to the synthesis of a wide range of organic molecules.
Used in Drug Development:
(S)-Methyl 2-Bi-((Tert-Butoxycarbonyl)Amino)-5-Hydroxypentanoate is used as a starting material for the development of new drugs. Its potential pharmaceutical applications are being explored, with the aim of creating novel therapeutic agents to address various medical conditions.

Upstream product

• 206128-03-2 (S)-dimethyl 2-(bis(tert-butoxycarbonyl)amino)pentanedioate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 6525-53-7 L-glutamic acid dimethyl ester 
• 74-88-4 methyl iodide 
• 192314-71-9 methyl (S)-2-N,N-di(tert-butoxycarbonyl)amino-5-oxopentanoate 
• 59279-60-6 dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate 
• 23150-65-4 L-glutamic dimethyl ester hydrochloride 
• 56-86-0 L-glutamic acid 

Downstream Products

• 13734-28-6 Boc-Lys-OH 

Relevant articles and documents

Structure-Activity Relationships for the Marine Natural Product Sintokamides: Androgen Receptor N-Terminus Antagonists of Interest for Treatment of Metastatic Castration-Resistant Prostate Cancer

Synthetic analogues of the marine natural product sintokamides have been prepared in order to investigate the structure-activity relationships for the androgen receptor N-terminal domain (AR NTD) antagonist activity of the sintokamide scaffold. An in vitro LNCaP cell-based transcriptional activity assay with an androgen-driven luciferase (Luc) reporter was used to monitor the potency of analogues. The data have shown that the chlorine atoms on the leucine side chains are essential for potent activity. Analogues missing the nonchlorinated methyl groups of the leucine side chains (C-1 and C-17) are just as active and in some cases more active than the natural products. Analogues with the natural R configuration at C-10 and the unnatural R configuration at C-4 are most potent. Replacing the natural propionamide N-terminus cap with the more sterically hindered pivaloylamide N-terminus cap leads to enhanced potency. The tetramic acid fragment and the methyl ether on the tetramic acid fragment are essential for activity. The SAR optimized analogue 76 is more selective, easier to synthesize, more potent, and presumed to be more resistant to proteolysis than the natural sintokamides.

HERBICIDAL COMPOSITIONS

The present invention relates novel herbicidal combinations and their use in controlling plants or inhibiting plant growth. In particular, herbicidal combinations of the invention comprise at least one pyridazine derivative as defined herein, in combination with at least one futher herbicide that is an acetoclactase synthase (ALS) inhibitor.

HERBICIDAL COMPOSITIONS

The present invention relates to novel herbicidal combinations and their use in controlling plants or inhibiting plant growth. In particular, herbicidal combinations of the invention comprise at least one pyridazine derivative of Formula (I), in combination with at least one futher herbicide that is a non-selective herbicide, a herbicide that acts through the inhibition of protoporphoryinogen oxidase, or a herbicide that inhibits photosystem II in photosynthesis.