36804-50-9

Basic information

• Product Name: 1H-Indole, 5-methyl-2,3-diphenyl-
• Synonyms: 1H-Indole, 5-methyl-2,3-diphenyl-
• CAS NO: 36804-50-9
• Molecular Formula: C₂₁H₁₇N
• Molecular Weight: 283.37
• Mol File: 36804-50-9.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 463.7°Cat760mmHg
• Flash Point: 203.4°C
• Appearance: /
• Density: 1.139g/cm³
• Vapor Pressure: 2.47E-08mmHg at 25°C
• Refractive Index: 1.666
• CAS DataBase Reference: 1H-Indole, 5-methyl-2,3-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 5-methyl-2,3-diphenyl-(36804-50-9)
• EPA Substance Registry System: 1H-Indole, 5-methyl-2,3-diphenyl-(36804-50-9)

Safety Data

• Hazardous Substances Data: 36804-50-9(Hazardous Substances Data)

Usage

Class of compounds

Indoles

Structure

Bicyclic heterocycles consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring

Substituents

5-methyl group, 2and 3diphenyl groups

Unique structure and chemical properties

Due to the presence of the substituents

Uses

Organic synthesis and medicinal chemistry

Building block

For the preparation of various pharmaceuticals and bioactive molecules

Value in research

Wide range of applications and potential biological activities

InChI:InChI=1/C21H17N/c1-15-12-13-19-18(14-15)20(16-8-4-2-5-9-16)21(22-19)17-10-6-3-7-11-17/h2-14,22H,1H3

Upstream product

• 540-23-8 p-toluidine hydrochloride 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 106-49-0 p-toluidine 
• 103973-39-3 deoxybenzoin-p-tolylhydrazone 
• 854891-59-1 6-methyl-3,4-diphenyl-5,6,7,8-tetrahydro-cinnoline 
• 78604-82-7 α-p-toluidino-deoxybenzoin 
• 142-04-1 aniline hydrochloride 
• 5722-91-8 1,2-diphenyl-2-(phenylamino)ethanone 
• 17655-74-2 β-ethoxystyrene 
• 4747-15-3 1-(2-methoxyvinyl)benzene 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 536-74-3 phenylacetylene 
• 100-52-7 benzaldehyde 
• 29289-13-2 2-iodo-4-methylaniline 

Downstream Products

• 36804-51-0 1-(5-methyl-2,3-diphenyl-1H-indol-1-yl)ethan-1-one 
• 52263-96-4 N-(2-benzoyl-4-methylphenyl)benzamide 
• 120136-98-3 5-methyl-2,3-diphenyl-1H-indol-6-carboxaldehyde 
• 83824-13-9 5-methyl-2,3-diphenylindole-1-carboxaldehyde 
• 17852-28-7 2-amino-5-methylbenzophenone 
• 1470-57-1 2-hydroxy-5-methylbenzophenone 
• 70453-82-6 6-methyl-4-phenyl-quinolin-2-ol 
• 125720-27-6 5,9-dimethyl-2,3-diphenyl-7,7-dicarbethoxy-6-ethyl-6,7,8,9-tetrahydrobenzo<6,7-f>indole 
• 125720-26-5 2,3-diphenyl-5-methyl-6-<(4',4'-dicarbethoxy-5'-ethyl)-1-pentenyl>indole 
• 125720-25-4 2,3-diphenyl-5-methyl-6-<(1',1'-dicarbethoxy-2'-ethyl)>indole 
• 125720-24-3 diethyl-2-<(2',3'-diphenyl-5'-methyl-6'-indolyl)methylene>malonate 

Relevant articles and documents

Palladium-catalyzed synthesis of α-aryl acetophenones from styryl ethers and aryl diazonium saltsviaregioselective Heck arylation at room temperature

Preparation of α-aryl acetophenones from styryl ethers and aryldiazonium salts is described. The reaction is catalyzed by palladium acetate at room temperature in the absence of ligand and base. The developed method is highly attractive in terms of reaction conditions, substrate scope, functional group tolerance and yields. Synthetic applications of the present method are demonstrated by preparing α-aryl indoles and 3-aryl isocoumarin from styryl ethers.

Synthesis of Unprotected and Highly Substituted Indoles by the Ruthenium(II)-Catalyzed Reaction of Phenyl Isocyanates with Diaryl/Diheteroaryl Alkynes/Ethyl-3-phenyl Propiolates

A one-pot transformation has been developed for the synthesis of unprotected and highly substituted indoles by an in situ installed carbamide-directed Ru(II)-catalyzed intermolecular oxidative annulation of phenyl isocyanates with diaryl/diheteroaryl alkynes/ethyl phenyl propiolates in the presence of Cu(OAc)2·H2O as an oxidant and AgSbF6 as an additive at 120 °C within 3 h.

Method for preparing indole compounds by using rhodium/carbon as catalyst

The invention provides a method for preparing indole compounds by using rhodium/carbon as a catalyst. Corresponding indole compounds are formed through subjecting aniline and analogs thereof and alkyne to a catalytic cyclization reaction in the presence of the rhodium/carbon. The method has the beneficial effects that the preparation method is simple in process, the raw materials are cheap and readily available, the yield is high, inert-gas protection is not required, and the reaction temperature is relatively moderate.