36881-02-4

Basic information

• Product Name: 1,3-Dioxolane, 2-(4-chlorophenyl)-2-methyl-
• CAS NO: 36881-02-4
• Molecular Formula: C10H11ClO2
• Molecular Weight: 198.649
• Mol File: 36881-02-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxolane, 2-(4-chlorophenyl)-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolane, 2-(4-chlorophenyl)-2-methyl-(36881-02-4)
• EPA Substance Registry System: 1,3-Dioxolane, 2-(4-chlorophenyl)-2-methyl-(36881-02-4)

Safety Data

• Hazardous Substances Data: 36881-02-4(Hazardous Substances Data)

Usage

Common Uses

Solvent
Synthesis of pharmaceuticals
Synthesis of other organic compounds

Physical State

Colorless, flammable liquid

Odor

Slightly sweet

Solubility

Soluble in water and many organic solvents

Toxicity

Toxic if ingested
Toxic if inhaled

Potential Hazards

Skin irritation upon contact
Eye irritation upon contact

Safety Precautions

Handle with proper safety measures

Disposal

Dispose of in accordance with local regulations

Upstream product

• 873-73-4 4-n-chlorophenylacetylene 
• 107-21-1 ethylene glycol 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 10359-10-1 2-(4-chlorophenyl)-2-methyl-1,3-dithiane 
• 99-91-2 para-chloroacetophenone 
• 19073-16-6 4-(2-methyl-[1,3]dioxolan-2-yl)-phenylamine 
• 117530-17-3 2-(4'-methoxy-[1,1'-biphenyl]-4-yl)-2-methyl-1,3-dioxolane 
• 6135-51-9 2-([1,1'-biphenyl]-4-yl)-2-methyl-1,3-dioxolane 
• 3674-77-9 2-methyl-2-phenyl-1,3-dioxolane 
• 1401468-45-8 2-(2-allylphenyl)-1,3-dioxolane 
• 1401468-44-7 2-(4-(2-ethoxy-2-(2,2,2-trifluoroethoxy)ethyl)phenyl)-2-methyl-1,3-dioxolane 
• 1401468-43-6 2-(4-(2-ethoxy-2-methoxyethyl)phenyl)-2-methyl-1,3-dioxolane 
• 1401468-42-5 5-(4-(2-methyl-1,3-dioxolan-2-yl)benzyldihydrofuran-2(3H))-one 
• 219822-49-8 2-(4-allylphenyl)-2-methyl-1,3-dioxolane 
• 115382-34-8 2-acetyl-5-chlorobenzoic acid 

Relevant articles and documents

Cyclopentyl methyl ether-NH4X: A novel solvent/catalyst system for low impact acetalization reactions

Cyclopentyl methyl ether, a low impact ether forming a positive azeotrope with water, was successfully employed as a solvent in the synthesis of 1,3-dioxanes and 1,3-dioxolanes carried out under Dean-Stark conditions by the acetalization of aliphatic and aromatic aldehydes or ketones, employing ammonium salts as environmentally friendly acidic catalysts.

Regioselective transformation of alkynes into cyclic acetals and thioacetals with a gold(I) catalyst: comparison with Br?nsted acid catalysts

Au(I) catalyzes the transformation of alkynes into cyclic acetals and thioacetals at much higher rate than Br?nsted acids. The reaction appears to be general for a range of alkynes and diols or dithiols, which are efficiently transformed with high selectivities. One of the salient features of this reaction process is the high reactivity of the enol ether or enol thioether intermediates, which undergo a rapid isomerization reaction to afford the cyclic acetals or thioacetals, so that isolation or subsequent activation processes are not required. This type of reactions allows us to synthesize a series of fragrances.

NOVEL METHODS FOR THE TREATMENT OF INFLAMMATORY DISEASES

Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as a part of combination therapy. Novel compounds of formula (I) are also provided for.