369-32-4

Basic information

• Product Name: 4-FLUORO-3-METHYLACETOPHENONE
• Synonyms: 4-FLUORO-3-METHYLACETOPHENONE;1-(4-Fluoro-3-methylphenyl)ethanone;4'-Fluoro-3'-methylacetophenon;4'-Fluoro-3'-methylacetophenone, JRD, 97%;4'-Fluoro-3'-methyacetophenone;1-(4-fluoro-3-Methylphenyl)ethan-1-one;3-Methyl-4-fluoroacetophenone;Ethanone,1-(4-fluoro-3-Methylphenyl)-
• CAS NO: 369-32-4
• Molecular Formula: C₉H₉FO
• Molecular Weight: 152.17
• Product Categories: Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 369-32-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 215°C(lit.)
• Flash Point: 86.5 °C
• Appearance: /
• Density: 1.075 g/cm³
• Vapor Pressure: 0.093mmHg at 25°C
• Refractive Index: 1.5128
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: 4-FLUORO-3-METHYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-3-METHYLACETOPHENONE(369-32-4)
• EPA Substance Registry System: 4-FLUORO-3-METHYLACETOPHENONE(369-32-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 369-32-4(Hazardous Substances Data)

Usage

Description

4-FLUORO-3-METHYLACETOPHENONE is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals and organic compounds. It is characterized by its unique molecular structure, which includes a fluorine atom at the 4' position and a methyl group at the 3' position on the acetophenone backbone.

Uses

Used in Pharmaceutical Industry:
4-FLUORO-3-METHYLACETOPHENONE is used as a pharmaceutical intermediate for the development of various drugs. Its unique structure allows for the creation of novel compounds with potential therapeutic applications, making it a valuable asset in the pharmaceutical sector.
Used in Organic Synthesis:
In the field of organic synthesis, 4-FLUORO-3-METHYLACETOPHENONE serves as an essential intermediate for the production of a wide range of organic compounds. Its versatile structure enables chemists to synthesize various molecules with different functional groups, further expanding its applications in research and development.

InChI:InChI=1/C9H9FO/c1-6-5-8(7(2)11)3-4-9(6)10/h3-5H,1-2H3

Upstream product

• 95-52-3 2-Fluorotoluene 
• 75-36-5 acetyl chloride 
• 181827-49-6 1-(2-chloro-4-fluoro-5-methylphenyl)ethan-1-one 
• 452-75-5 4-chloro-2-fluorotoluene 
• 252561-07-2 4-acetyl-2-methylphenyl trifluoromethanesulfonate 
• 452-68-6 1-fluoro-4-iodo-2-methylbenzene 
• 431-03-8 dimethylglyoxal 

Downstream Products

• 76475-79-1 1-(4-Fluoro-3-methyl-phenyl)-3-{4-[3-(4-fluoro-3-methyl-phenyl)-3-oxo-propyl]-piperazin-1-yl}-propan-1-one; hydrochloride 
• 76485-26-2 3-Dibenzylamino-1-(4-fluoro-3-methyl-phenyl)-propan-1-one; hydrochloride 
• 81593-26-2 4-fluoro-3-methylphenylglyoxal 
• 87054-26-0 2,3-Bis-(4-fluoro-3-methyl-phenyl)-butane-2,3-diol 
• 63529-31-7 2-bromo-1-(4-fluoro-3-methyl-phenyl)-ethanone 
• 146299-76-5 methyl 4-fluoro-3-methylbenzoyl acetate 
• 584-73-6 4-fluorobenzal-4'-fluoro-2'-methylacetophenone 
• 440363-97-3 3-[2-(4-Fluoro-3-methyl-phenyl)-2-oxo-eth-(E)-ylidene]-5-methyl-1,3-dihydro-indol-2-one 
• 105321-48-0 3-methyl-4-fluoro-α-methylbenzylamine 
• 440363-92-8 3-[2-(4-fluoro-3-methyl-phenyl)-2-oxo-ethyl]-3-hydroxy-5-methyl-1,3-dihydro-indol-2-one 
• 70059-35-7 2-(4-Fluoro-3-methyl-phenyl)-1H-indole 
• 7394-02-7 1-(4-fluoro-3-methylphenyl)-3-phenyl-2-propen-1-one 
• 127055-73-6 (E)-3-(2-Chloro-phenyl)-1-(4-fluoro-3-methyl-phenyl)-propenone 
• 97311-37-0 5-Fluoro-3-[2-(4-fluoro-3-methyl-phenyl)-2-oxo-ethyl]-3-hydroxy-1,3-dihydro-indol-2-one 

Relevant articles and documents

Metal-Free Photoinduced Transformation of Aryl Halides and Diketones into Aryl Ketones

The acylation of aryl halides to prepare aryl ketones without metal catalyst represents an important yet challenging topic towards more sustainable ketone synthesis. Herein, we describe a simple and efficient metal-free protocol for the acylation of aryl halides with diketone under the irradiation of light utilizing N-methylpiperidine as base under an air atmosphere. This reaction can tolerate a wide range of functional groups and the corresponding ketones can be obtained in modest to good yields.

Thiyl radical promoted chemo- and regioselective oxidation of CC bonds using molecular oxygen: Via iron catalysis

The first example of the thiyl radical promoted ligand-free iron-catalyzed oxidative cleavage of alkenes using molecular oxygen (1 atm) has been developed. The reaction proceeds under mild reaction conditions with high efficiency and high chemo- and regioselectivity. It features a broad substrate scope and excellent functional group compatibility, enabling facile access to valuable molecules for application in medicinal chemistry. Preliminary mechanistic studies reveal that a vital intermediate dioxetane might be involved in the reaction and a thiyl radical plays a synergistic role in facilitating the selective oxidation of the CC bond.

Accelerating palladium-catalyzed C-F bond formation: Use of a microflow packed-bed reactor

A flow process for Pd-catalyzed C-F bond formation is described. A microreactor with a packed-bed design allows for easy handling of large quantities of insoluble CsF with precise control over reaction times, efficient mixing, and the ability to safely handle elevated temperatures and pressures. A variety of aryl triflates, including heteroaryl ones, were converted into aryl fluorides in short reaction times (see scheme).