369-43-7

Basic information

• Product Name: 2-Amino-4'-fluoroacetophenone
• Synonyms: 4-Fluorophenacylamine;alpha-Amino-4'fluoroacetophenone;α-Amino-4’-fluoroacetophenone;2-AMINO-4’-FLUOROACETOPHENONE;2-Amino-4-fluoroacetophenone/2-amino-4'-fluoroacetophenone;α-Amino-4’-fluoroacetophenone hydrochloride;a-Amino-4-fluoroacetophenone;a-Amino-4-fluoroacetophenone hydrochloride
• CAS NO: 369-43-7
• Molecular Formula: C₈H₈FNO
• Molecular Weight: 153.15
• Mol File: 369-43-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 262.7°Cat760mmHg
• Flash Point: 112.7°C
• Appearance: /
• Density: 1.188g/cm³
• PKA: 6.93±0.29(Predicted)
• CAS DataBase Reference: 2-Amino-4'-fluoroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4'-fluoroacetophenone(369-43-7)
• EPA Substance Registry System: 2-Amino-4'-fluoroacetophenone(369-43-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 369-43-7(Hazardous Substances Data)

Usage

General Description

2-Amino-4'-fluoroacetophenone is a chemical compound with the molecular formula C8H8FNO. It is a derivative of acetophenone, and it contains an amino group and a fluorine atom attached to the phenyl ring. 2-Amino-4'-fluoroacetophenone is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. It is also used as a building block in the production of various fine chemicals and agrochemicals. 2-Amino-4'-fluoroacetophenone has potential applications in the pharmaceutical industry, specifically in the development of new drugs and medications. However, it is important to handle this compound with care, as it may pose health and safety risks if not properly managed and used in accordance with recommended guidelines.

Upstream product

• 403-29-2 2-bromo-4'-fluoroacetophenone 

Downstream Products

• 113485-27-1 N-(4'-fluorophenacyl)isonicotinamide 

Relevant articles and documents

Design, synthesis, and cytotoxic activity of novel 2H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidine derivatives

In this study, a series of novel 2H-imidazo [1, 2-c] pyrazolo [3, 4-e] pyrimidine derivatives were designed, synthesized, and evaluated for their cytotoxic activities. The in vitro cell growth inhibition assay of the target compounds indicated their selectivity in inhibiting the proliferation of blood tumor cells (K562, U937) and solid tumor cells (HCT116, HT-29). Compound 9b exhibited the highest antiproliferative activities against K562 (IC50 = 5.597 μM) and U937 (IC50 = 3.512 μM). Based on the flow cytometry assays, compound 9b caused obvious induction of cell apoptosis and cell arrest at the S phase. Furthermore, western blot analysis revealed that compound 9b upregulated the expression of Bax, downregulated the levels of Bcl-2, and further activated caspase-3 in K562 cells. Therefore, compound 9b may be a potential anticancer agent that deserves further investigation.

Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists

A new series of morpholine derivatives has been identified as selective DA D3 receptor antagonists; their in vitro profile and pharmacokinetic data are provided.

A QUINOLINE AMIDE DERIVATIVE AS AGENT AGAINST DISORDERS OF THE CNS

A compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, is provided (Formula I) as is a process for its preparation and methods for its use in therapy, particularly in treating CNS or CNS-mediated disorders.