36913-39-0 Usage
Description
MPP+ IODIDE, also known as 1-Methyl-4-phenylpyridinium, is a potent neurotoxin that acts as a selective cytostatic agent in small-cell lung cancer cell lines with neuroendocrine properties. It is an active metabolite of the dopaminergic neurotoxin MPTP and is known to induce neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. MPP+ IODIDE is a potential neurotoxin that can induce Parkinson's disease in animal models and mediates apoptosis through the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. It also modulates the distribution of dopamine and elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.
Uses
Used in Pharmaceutical Industry:
MPP+ IODIDE is used as a dopaminergic neurotoxin for its selective cytostatic action in small-cell lung cancer cell lines with neuroendocrine properties. It is valuable in the study and development of treatments for neuroendocrine cancers.
Used in Neurological Research:
MPP+ IODIDE is used as a neurotoxin in the research of Parkinson's disease and other neurodegenerative disorders. Its ability to induce neurotoxicity and apoptosis in animal models makes it a useful tool for understanding the underlying mechanisms of these diseases and for testing potential therapeutic interventions.
Used in Cellular and Molecular Biology:
MPP+ IODIDE is used as a research tool to study the effects of mitochondrial dysfunction, oxidative stress, and nitric oxide production on neuronal cells. Its ability to modulate dopamine distribution and activate neuronal nitric oxide synthase (nNOS) provides insights into the complex interactions between these factors and their role in neurodegenerative processes.
Biochem/physiol Actions
MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.
Check Digit Verification of cas no
The CAS Registry Mumber 36913-39-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,9,1 and 3 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 36913-39:
(7*3)+(6*6)+(5*9)+(4*1)+(3*3)+(2*3)+(1*9)=130
130 % 10 = 0
So 36913-39-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H9N.HI/c1-2-4-10(5-3-1)11-6-8-12-9-7-11;/h1-9H;1H
36913-39-0Relevant articles and documents
Cation-π interactions secure aggregation induced emission of planar organic luminophores
Leduskrasts, Kaspars,Kinens, Artis,Suna, Edgars
, p. 12663 - 12666 (2019)
The use of non-covalent intermolecular π+-π interactions between quaternary pyridinium or imidazolium cations and aromatic π systems is an efficient approach to achieve AIE in planar purely organic luminophores.
MATERIALS FOR USE IN AN AQUEOUS ORGANIC REDOX FLOW BATTERY
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Paragraph 0256; 0260, (2018/05/15)
Described herein are aqueous organic redox flow batteries that include a first redox active material that can include a metallocene or a salt thereof, and a second redox active material that can include a viologen or a salt thereof. The aqueous organic re
Photophysical and electrochemical properties of platinum(ii) complexes bearing a chromophore-acceptor dyad and their photocatalytic hydrogen evolution
Zhang, Gui-Ju,Gan, Xin,Xu, Quan-Qing,Chen, Yong,Zhao, Xi-Juan,Qin, Biao,Lv, Xiao-Jun,Lai, Siu-Wai,Fu, Wen-Fu,Che, Chi-Ming
experimental part, p. 8421 - 8429 (2012/07/30)
A series of platinum(ii) complexes bearing a chromophore-acceptor dyad obtained by reacting 4-(p-bromomethylphenyl)-6-phenyl-2,2′-bipyridine or 4′-(p-bromomethylphenyl)-2,2′:6′,2′′-terpyridine with pyridine, 4-phenylpyridine, 4,4′-bipyridine, 1-methyl-4-(