36930-64-0

Basic information

• Product Name: 1,8-I-AEDANS
• Synonyms: N-(IODOACETYLAMINOETHYL)-8-NAPHTHYLAMINE-1-SULFONIC ACID;N-IODOACETYL-N'-(8-SULFO-1-NAPHTHYL)ETHYLENEDIAMINE;1,8-I-AEDANS;N-iodoacetyl-N'-(8-sulfo-1-naphthyl)*ethylenediam;8-[[2-(iodoacetamido)ethyl]amino]naphthalene-1-sulphonic acid;N-IODOACETYL-N'-(8-SULFO-1-NAPHTHYL)*ETH YLENEDIAMIN;1,8-I-AEDANS, 8-[2-(2-Iodoacetamido)ethylamino]-1-naphthalenesulfonic acid;8-[[2-(Iodoacetylamino)ethyl]amino]-1-naphthalenesulfonic acid
• CAS NO: 36930-64-0
• Molecular Formula: C14H15IN2O4S
• Molecular Weight: 434.25
• EINECS: 253-278-2
• Product Categories: Fluorescent Labels and Indicators;Fluorescent Labels & Indicators;MTS & Sulfhydryl Active Reagents;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfonic/Sulfinic Acids;Sulfur Compounds
• Mol File: 36930-64-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 198-200°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: yellow/crystalline
• Density: 1.808 g/cm³
• Storage Temp.: Refrigerator
• Solubility: At least 0.05M in phosphate buffer at pH 7DMF, DMSO
• Stability: Sensitive to Light
• CAS DataBase Reference: 1,8-I-AEDANS(CAS DataBase Reference)
• NIST Chemistry Reference: 1,8-I-AEDANS(36930-64-0)
• EPA Substance Registry System: 1,8-I-AEDANS(36930-64-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 36930-64-0(Hazardous Substances Data)

Usage

Description

1,8-I-AEDANS, also known as 8-(2-Iodoacetyl)aminonaphthalene-1-sulfonic acid, is a fluorescent sulfhydryl reagent that is sensitive to photo-catalyzed degradation in both aqueous solutions and organic solvents. It is a tan solid that readily reacts with thiol compounds and sulfhydryl groups to provide photo-stable covalent derivatives.

Uses

Used in Biochemical Research:
1,8-I-AEDANS is used as a fluorescent labeling agent for biomolecules, such as proteins and peptides, containing free thiol groups. The application reason is its ability to form covalent bonds with these groups, allowing for the detection and analysis of biomolecular interactions, conformational changes, and protein folding.
Used in Analytical Chemistry:
1,8-I-AEDANS is used as a detection reagent in high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE) for the analysis of thiol-containing compounds. The application reason is its high sensitivity and selectivity towards thiols, enabling the accurate quantification and identification of these compounds in complex samples.
Used in Pharmaceutical Industry:
1,8-I-AEDANS is used as a tool in drug discovery and development for the identification and characterization of thiol-dependent enzymes and proteins. The application reason is its ability to label and track the activity of these proteins, which can be crucial for understanding their role in various diseases and the development of targeted therapeutics.
Used in Environmental Monitoring:
1,8-I-AEDANS is used as a sensitive probe for the detection of thiol-containing pollutants and contaminants in environmental samples. The application reason is its high sensitivity and specificity towards thiols, allowing for the accurate measurement of these compounds at low concentrations, which is essential for assessing their impact on ecosystems and human health.