369362-96-9 Usage
Description
(2S,3R)-2-amino-4-chloro-1-phenylbutan-3-ol hydrochloride is a chiral chemical compound derived from 4-chloro-1-phenylbutan-2-ol, featuring two stereocenters at the 2nd and 3rd carbons, designated as (2S,3R). This molecule is characterized by the presence of an amino group, a hydroxyl group, a chlorine atom, and a phenyl ring. Its hydrochloride salt form enhances solubility in aqueous solutions, which is advantageous for pharmaceutical formulations. (2S,3R)-2-amino-4-chloro-1-phenylbutan-3-ol hydrochloride holds potential for therapeutic applications and is frequently utilized in pharmaceutical research.
Uses
Used in Pharmaceutical Research:
(2S,3R)-2-amino-4-chloro-1-phenylbutan-3-ol hydrochloride serves as an important compound in pharmaceutical research due to its unique structural features. Its potential therapeutic applications are being explored, with the aim of developing it into a drug candidate for various medical conditions.
Used in Drug Formulation:
The hydrochloride salt form of (2S,3R)-2-amino-4-chloro-1-phenylbutan-3-ol increases its solubility in aqueous solutions, making it more suitable for the development of pharmaceutical formulations. This improved solubility can facilitate the compound's absorption and distribution within the body, which is crucial for its effectiveness as a therapeutic agent.
Check Digit Verification of cas no
The CAS Registry Mumber 369362-96-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,9,3,6 and 2 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 369362-96:
(8*3)+(7*6)+(6*9)+(5*3)+(4*6)+(3*2)+(2*9)+(1*6)=189
189 % 10 = 9
So 369362-96-9 is a valid CAS Registry Number.
369362-96-9Relevant articles and documents
PROCESS FOR THE PREPARATION OF ATAZANAVIR OR ITS BISULFATE SALT
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Paragraph 0055; 0056; 0057; 0058, (2014/12/09)
The present invention relates to an improved process for the preparation of atazanavir bisulfate, an inhibitor of retroviral aspartate protease. The process of the present invention comprises conversion of 1,1-dimethylethyl[(2S,3R)-4-chloro-3-hydroxy-phenylbutan-2-yl]carbamate (Formula II) into 1-[4-(pyridine-2-yl)-phenyl]-4(S)-5 hydroxy-2-N-tert-butoxycarbonylamino-5(S)—N—(N-methoxycarbonyl-(L)-tert-leucyl)amino-6-phenyl-2-azahexane (Formula VII) without isolating intermediate compounds formed therein, followed by its subsequent conversion to atazanavir or its bisulfate salt.
Production method of aminochlorohydrin sulfate
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Page/Page column 21, (2010/11/26)
Highly pure (2R,3S)-3-tert-butoxycarbonylamino-1-chloro-2-hydroxy-4-phenylbutane or (2S,3R)-3-tert-butoxycarbonylamino-1-chloro-2-hydroxy-4-phenylbutane may be conveniently produced in high yield by: (a) reacting compound (1) with lithiumchloromethane to give compound (2) and at least a byproduct; (b) dissolving compound (2) and the byproduct in a polar solvent and adding water to the solution to precipitate compound (2) as crystals; (c) reducing the crystals of compound (2) to give compound (3) and at least its diastereomer as an impurity; (d) adding sulfuric acid thereto to give compound (4) and at least its diastereomer as an impurity; and (e) precipitating compound (4) as crystals from a solution containing acetic acid ester or acetic acid ester.
