36978-49-1

Basic information

• Product Name: 3-(P-CHLOROBENZOYL)-BUTYRIC ACID
• Synonyms: CHEMBRDG-BB 5879341;3-(P-CHLOROBENZOYL)-BUTYRIC ACID 98%;3-(p-Chlorobenzoyl)butyric acid,98%;3-(P-CHLOROBENZOYL)-BUTYRIC ACID
• CAS NO: 36978-49-1
• Molecular Formula: C₁₁H₁₁ClO₃
• Molecular Weight: 226.66
• Mol File: 36978-49-1.mol
• Article Data: 15

Chemical Properties

• Melting Point: 124-129 °C
• Boiling Point: 324.6°C (rough estimate)
• Flash Point: 209.7°C
• Appearance: /
• Density: 1.2401 (rough estimate)
• Vapor Pressure: 6.51E-08mmHg at 25°C
• Refractive Index: 1.4530 (estimate)
• CAS DataBase Reference: 3-(P-CHLOROBENZOYL)-BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(P-CHLOROBENZOYL)-BUTYRIC ACID(36978-49-1)
• EPA Substance Registry System: 3-(P-CHLOROBENZOYL)-BUTYRIC ACID(36978-49-1)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 36978-49-1(Hazardous Substances Data)

Usage

Chemical Properties

Pink to brown powder

InChI:InChI=1/C11H11ClO3/c12-9-6-4-8(5-7-9)10(13)2-1-3-11(14)15/h4-7H,1-3H2,(H,14,15)

Upstream product

• 40297-26-5 (±)-2-(4-chlorophenyl)cyclopentan-1-one 
• 108-55-4 glutaric anhydride, 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 108-90-7 chlorobenzene 
• 1129273-72-8 (1S,2R)-2-(4-chlorophenyl)cyclohexanol 

Downstream Products

• 1258204-07-7 5-(4-chlorophenyl)hex-5-enoic acid 
• 1258204-00-0 (S)-6-(4-chlorophenyl)-6-(iodomethyl)tetrahydro-2H-pyran-2-one 
• 1370729-69-3 (R)-6-(4-chlorophenyl)-6-(iodomethyl)tetrahydro-2H-pyran-2-one 
• 112607-35-9 (+)-(R)-δ-(4-chlorophenyl)-δ-valerolactone 
• 112607-05-3 δ-(p-chlorophenyl)-δ-valerolactone 
• 26673-31-4 6-chloro-3,4-dihydronaphthalen-1(2H)-one 
• 161725-12-8 5-(4-chlorophenyl)pentanoic acid 
• 54029-03-7 ethyl 5-(4-chlorophenyl)-5-oxopentanoate 
• 1242183-68-1 3-(6-(4-chlorophenyl)-4-(2-hydroxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)propanoic acid 
• 1242183-67-0 3-(6-(4-chlorophenyl)-4-(furan-2-yl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)propanoic acid 
• 1242183-73-8 3-(6-(4-chlorophenyl)-4-(pyridin-2-yl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)propanoic acid 

Relevant articles and documents

Method for synthesizing 4-(4-fluorobenzoyl) butyric acid and analogues thereof in continuous flow microreactor

The invention relates to a method for synthesizing 4-(4-fluorobenzoyl) butyric acid and analogues thereof in a continuous flow microreactor, which comprises the following steps: (1) uniformly mixing a compound 1 and a compound 2 to obtain a homogeneous phase solution A; (2) uniformly mixing aluminum trichloride, a compound 1 and an organic solvent to obtain a homogeneous phase solution B; (3) diluting concentrated hydrochloric acid with water to prepare a solution C; and (4) transferring the homogeneous phase solution A and the homogeneous phase solution B into a first micro-reaction module for a Friedel-Crafts acylation reaction, after the reaction is finished, transferring the obtained reaction solution and the solution C into a second micro-reaction module for quenching reaction, and then performing liquid separation, washing and vacuum concentration to obtain a target compound 3; wherein the specific synthesis route is as follows. By adopting the method disclosed by the invention, the target product can be continuously and rapidly synthesized, aluminum trichloride is not needed for treatment, the reaction condition is mild, the reaction time is short, and the yield is high and reaches 90% or above.

Iridium-Catalyzed Asymmetric Hydrogenation of ?- A nd ?-Ketoacids for Enantioselective Synthesis of ?- A nd ?-Lactones

A highly efficient asymmetric hydrogenation of ?- A nd ?-ketoacids was developed by using a chiral spiro iridium catalyst (S)-1a, affording the optically active ?- A nd ?-hydroxy acids/lactones in high yields with excellent enantioselectivities (up to >99% ee) and turnover numbers (TON up to 100000). This protocol provides an efficient and practical method for enantioselective synthesis of Ezetimibe.

Cooperative iodine and photoredox catalysis for direct oxidative lactonization of carboxylic acids

A new method for the formation of γ- and δ-lactones from carboxylic acids through direct conversion of benzylic C-H to C-O bonds is described. The reaction is conveniently induced by visible light and relies on a mild cooperative catalysis by the combination of molecular iodine and an organic dye.