36997-13-4

Basic information

• Product Name: Piperidine, 1,1'-[1,4-phenylenebis(methylene)]bis-
• Synonyms: 1,4-bis(piperidin-1-ylmethyl)benzene;1,1'-p-phenylenedimethyl-bis-piperidine;1,1'-(benzene-1,4-diyldimethanediyl)dipiperidine;{[4-(piperidylmethyl)phenyl]methyl}piperidine;1,4-bis(piperidinomethyl)benzene;N,N'-(p-Xylylen)-dipiperidin;Piperidine,1,1'-[1,4-phenylenebis(methylene)]bis;1,4-Bis-piperidinomethyl-benzol
• CAS NO: 36997-13-4
• Molecular Formula: C18H28N2
• Molecular Weight: 272.434
• Mol File: 36997-13-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Piperidine, 1,1'-[1,4-phenylenebis(methylene)]bis-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1,1'-[1,4-phenylenebis(methylene)]bis-(36997-13-4)
• EPA Substance Registry System: Piperidine, 1,1'-[1,4-phenylenebis(methylene)]bis-(36997-13-4)

Safety Data

• Hazardous Substances Data: 36997-13-4(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 623-27-8 terephthalaldehyde, 
• 15088-30-9 1,4-phenylenebis(piperidin-1-ylmethanone) 
• 623-24-5 1,4-bis(bromomethyl)benzene 

Downstream Products

• 102207-40-9 1,1'-(1,4-phenylene-bis(methylene))bis(1-ethylpiperidinium) dibromide 

Relevant articles and documents

High-Throughput Screening of Reductive Amination Reactions Using Desorption Electrospray Ionization Mass Spectrometry

This study describes the latest generation of a high-throughput screening system that is capable of screening thousands of organic reactions in a single day. This system combines a liquid handling robot with desorption electrospray ionization (DESI) mass spectrometry (MS) for a rapid reaction mixture preparation, accelerated synthesis, and automated MS analysis. A total of 3840 unique reductive amination reactions were screened to demonstrate the throughputs that are capable with the system. Products, byproducts, and intermediates were all monitored in full-scan mass spectra, generating a complete view of the reaction progress. Tandem mass spectrometry experiments were conducted to verify the identity of the products formed. The amine and electrophile reactivity trends represented in the data match what is expected from theory, indicating that the system accurately models the reaction performance. The DESI results correlated well with those generated using more traditional mass spectrometry techniques like liquid chromatography-mass spectrometry, validating the data generated by the system.

Symmetrical bis-tertiary amines as novel CXCR4 inhibitors

CXCR4 inhibitors are promising agents for the treatment of cancer metastasis and inflammation. A series of novel tertiary amine derivatives targeting CXCR4 were designed, synthesized, and evaluated. The central benzene ring linker and side chains were mod

Cesium carbonate-catalyzed reduction of amides with hydrosilanes

Cesium carbonate has been found to be an effective catalyst for the reduction of tertiary carboxamides with the simple, commercially available PhSiH3 under solvent-free conditions. The catalytic system can effectively reduce a range of amides under relatively mild conditions (from room temperature to 80 C) to yield the corresponding amines in good to excellent yields (71-100%) and thus has the potential for practical applications.